Afatinib IMpurity J

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Product Name: Afatinib IMpurity J
CAS No.: 1456696-14-2
Chemical Name: Afatinib IMpurity J
Synonyms: Afatinib B;Afatinib IMpurity J;Afatinib Impurity J HCl;(S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide;(2E)-4-(Dimethylamino)-N-{4-oxo-7-[(3S)-tetrahydro-3-furanyloxy]-1,4-dihydro-6-quinazolinyl}-2-butenamide;(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;2-Butenamide, N-[3,4-dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity);Afatinib impurity 8/(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
CBNumber: CB82706586
Molecular Formula: C18H22N4O4
Formula Weight: 358.39
MOL File: 1456696-14-2.mol

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Afatinib IMpurity J Property

Density: 1.33±0.1 g/cm3(Predicted)
pka: 11.89±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D495325
Product name: (2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Packaging: 1mg
Price: $165
Updated: 2021/12/16

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Afatinib IMpurity J Chemical Properties,Usage,Production

Uses

(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, s an impurity of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Afatinib IMpurity J Preparation Products And Raw materials

Raw materials

Preparation Products

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1456696-14-2, Afatinib IMpurity JRelated Search:

Afatinib IMpurity H Alfatinib maleate Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity I Afatinib Impurity K Afatinib Impurity 6 Afatinib IMpurity E 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Afatinib impurity 30 Afatinib Impurity 22 Afatinib Impurity 9 Afatinib-d6 Afatinib Impurity 74 Afatinib impurity 40 Afatinib impurity 33 Afatinib Impurity 14 Afatinib Impurity 18 Afatinib impurity 27

Afatinib IMpurity J

Afatinib Impurity J HCl

(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Afatinib impurity 8/(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

(2E)-4-(Dimethylamino)-N-{4-oxo-7-[(3S)-tetrahydro-3-furanyloxy]-1,4-dihydro-6-quinazolinyl}-2-butenamide

2-Butenamide, N-[3,4-dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-

(S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide

Afatinib B

(S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity)

1456696-14-2