DifluoroiodoMethyl phenyl sulfone
- Product Name
- DifluoroiodoMethyl phenyl sulfone
- CAS No.
- 802919-90-0
- Chemical Name
- DifluoroiodoMethyl phenyl sulfone
- Synonyms
- DifluoroiodoMethyl phenyl sulfone;(difluoroiodomethylsulfonyl)benzene;Benzene, [(difluoroiodomethyl)sulfonyl]-
- CBNumber
- CB82709840
- Molecular Formula
- C7H5F2IO2S
- Formula Weight
- 318.08
- MOL File
- 802919-90-0.mol
DifluoroiodoMethyl phenyl sulfone Property
- Boiling point:
- 312.4±42.0 °C(Predicted)
- Density
- 1.975±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to off-white Solid
Safety
- Safety Statements
- 24/25
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JK1711633
- Product name
- Difluoroiodomethylphenylsulfone
- Purity
- 98%
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 8573AJ
- Product name
- Difluoroiodomethylphenylsulfone
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 8573AJ
- Product name
- Difluoroiodomethylphenylsulfone
- Packaging
- 1g
- Price
- $358
- Updated
- 2021/12/16
- Product number
- PC911469
- Product name
- [(Difluoroiodomethyl)sulfonyl]benzene
- Purity
- 98%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- A264821
- Product name
- ((Difluoroiodomethyl)sulfonyl)benzene
- Purity
- 98%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
DifluoroiodoMethyl phenyl sulfone Chemical Properties,Usage,Production
Description
A visible light-catalysed direct and regioselective (phenylsulfonyl) difluoromethylation of imidazo[1,2-A]pyridines and benzo[d]-imidazo[2,1-b]thiazoles was carried out by DifluoroiodoMethyl phenyl sulfone under mild conditions. This synthetic methodology enables the introduction of a CF2SO2Ph group in an efficient and regioselective reaction through C-H bond functionalization with a broad substrate scope in good to excellent yields.
Uses
Iododifluoromethyl phenyl sulfone can be used for the difluoromethylation of alkenes and alkynes initiated by triethylborane/air or arenediazonium salt/titanium chloride in moderate to good yields.
Reactions
(1) Difluoromethylation of terminal alkenes and alkynes.
Synthesis
1535-65-5
802919-90-0
Difluoromethyl phenyl sulfone (192 mg, 1 mmol) and elemental iodine (508 mg, 4 mmol) were dissolved in DMF (4 mL) in a Schlenk flask under argon protection. The system was cooled to -30 °C and a solution of t-BuOK (448 mg, 4 mmol) in DMF (4 mL) was added slowly dropwise via syringe. The reaction temperature was maintained between -30 °C and -20 °C with continuous stirring for 1 h. The reaction progress was monitored by 19F NMR tracking. Upon completion of the reaction, the reaction was quenched by the addition of 1N HCl aqueous solution (5 mL) at -50 °C, followed by slow warming to room temperature. Saturated aqueous NaCl solution (10 mL) was added and the reaction mixture was extracted with ether (15 mL x 3). The organic phases were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=9:1) to afford the target product difluoroiodomethyl phenyl sulfone (294 mg, 92% yield), which is a colorless solid and turns red easily when exposed to light. The product characterization data were as follows: 1H NMR (500 MHz, CDCl3): δ 7.63 (t, J = 7.4 Hz, 2H), 7.79 (t, J = 7.4 Hz, 1H), 7.99 (d, J = 7.5 Hz, 2H); 13C NMR (125 MHz, CDCl3): δ 102.5 (t, J = 355 Hz), 128.1, 129.7, 131.3, 136.1; 19F NMR (470 MHz, CDCl3): δ -52.2; MS (EI, m/z): 318 (M+), 177, 142, 127; HRMS (EI): m/z calcd for C7H5F2IO2S (M+) 317.9023, found 317.9013. found 317.9013.
References
[1] GUO-JIE YIN; W. F; Mei Zhu. Visible-light mediated regioselective (phenylsulfonyl)difluoromethylation of fused imidazoles with iododifluoromethyl phenyl sulfone[J]. Heterocyclic Communications, 2017. DOI:10.1515/hc-2017-0101.
[2] YA LI. Radical (Phenylsulfonyl)difluoromethylation with Iododifluoromethyl Phenyl Sulfone[J]. The Journal of Organic Chemistry, 2007. DOI:10.1021/jo070618s.
DifluoroiodoMethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
DifluoroiodoMethyl phenyl sulfone Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 13524892556
- Fax
- (86) 21 51969655， QQ： 263541193
- sales-cn@potentpharm.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 010-61136123
- Fax
- +86 (10) 8857-9127
- pub02@greenherbs.com.cn
- Country
- China
- ProdList
- 4049
- Advantage
- 58
- Tel
- 18001959627(微信同号) 18001959627
- jjlchem2@163.com
- Country
- China
- ProdList
- 9981
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58