ChemicalBook > CAS DataBase List > (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID

(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID

Product Name: (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID
CAS No.: 157604-55-2
Chemical Name: (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID
Synonyms: (S)-SP5114;(S)-SNAP 5114;SNAP 5114 (S)-;(S)-SNAP-5114;(S)-SNAP5114, 10 mM in DMSO;(S)-SNAP-5114 >=98% (HPLC), solid;(S)SNAP5114,(S)-SNAP-5114,(S) SNAP5114;S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIP;1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-(S)-3-PIPERIDINECARBOXYLIC ACID;(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID
CBNumber: CB8271118
Molecular Formula: C30H35NO6
Formula Weight: 505.6
MOL File: 157604-55-2.mol

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(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID Property

Boiling point:: 643.9±55.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: H₂O: insoluble
form: solid
pka: 3.85±0.20(Predicted)
color: white
optical activity: [α]/D -8 to -13°, c =1 in chloroform-d

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1069
Product name: (S)-SNAP-5114
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: S1069
Product name: (S)-SNAP-5114
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $537
Updated: 2025/07/31

Tocris

Product number: 1561
Product name: (S)-SNAP5114
Purity: ≥98%(HPLC)
Packaging: 50
Price: $876
Updated: 2021/12/16

Tocris

Product number: 1561
Product name: (S)-SNAP5114
Purity: ≥98%(HPLC)
Packaging: 10
Price: $216
Updated: 2021/12/16

TRC

Product number: S590253
Product name: (S)-SNAP5114
Packaging: 10mg
Price: $195
Updated: 2021/12/16

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(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

(S)-SNAP 5114 is a GABA, GAT3 inhibitor.

Biological Activity

GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC 50 values are 5, 21 and 388 μ M for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo .

storage

Store at -20°C

References

[1]. borden la, dhar tg, smith ke, et al. cloning of the human homologue of the gaba transporter gat-3 and identification of a novel inhibitor with selectivity for this site. receptors channels, 1994, 2(3): 207-213.
[2]. pabel j, faust m, prehn c, et al. development of an (s)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(s)-snap-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4. chemmedchem, 2012, 7(7): 1245-1255.
[3]. dalby no. gaba-level increasing and anticonvulsant effects of three different gaba uptake inhibitors. neuropharmacology, 2000, 39(12): 2399-2407.
[4]. kataoka k, hara k, haranishi y, et al. the antinociceptive effect of snap5114, a gamma-aminobutyric acid transporter-3 inhibitor, in rat experimental pain models. anesth analg, 2013, 116(5): 1162-1169.

(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID Suppliers

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157604-55-2, (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACIDRelated Search:

DEMETON S medrylamine CHEMBRDG-BB 4010738 1-(2-benzhydryloxyethyl)piperidine moxastine (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID 4,4',4''-TRIMETHOXYTRITYL ALCOHOL Balofloxacin

(S)-SNAP 5114

(S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID

1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-(S)-3-PIPERIDINECARBOXYLIC ACID

S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIP

SNAP 5114 (S)-

(S)-SP5114

3-Piperidinecarboxylic acid, 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-, (3S)-

(S)-SNAP-5114 >=98% (HPLC), solid

(S)-1-(2-(Tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid

(S)SNAP5114,(S)-SNAP-5114,(S) SNAP5114

(S)-SNAP5114, 10 mM in DMSO

(<i>S</i>)-SNAP-5114

157604-55-2

GABA and Glycine Receptor Modulators

Ion Channels

Ligand-Gated Ion Channels

Cell Biology

Cell Signaling and Neuroscience

BioChemical

GABA/Glycine receptor