IWP-3
- Product Name
- IWP-3
- CAS No.
- 687561-60-0
- Chemical Name
- IWP-3
- Synonyms
- IWP-3;IWP 3;IWP3;IWP-3 >=98% (HPLC);Wnt Inhibitor IWP-3;2-[[3-(4-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide;2-{[3-(4-fluorophenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide;Acetamide, 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-;2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
- CBNumber
- CB82714671
- Molecular Formula
- C22H17FN4O2S3
- Formula Weight
- 484.59
- MOL File
- 687561-60-0.mol
IWP-3 Property
- Melting point:
- >248°C (dec.)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble2mg/mL (clear solution, warmed)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0533
- Product name
- IWP-3
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $149
- Updated
- 2022/05/15
- Product number
- 13953
- Product name
- IWP-3
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 13953
- Product name
- IWP-3
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 13953
- Product name
- IWP-3
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 13953
- Product name
- IWP-3
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $475
- Updated
- 2024/03/01
IWP-3 Chemical Properties,Usage,Production
Uses
IWP-3 is a potent inhibitor for porcupine which is known to catalyze the palmitoylation of Wnt proteins which are crucial in tumorigenesis.
Biological Activity
iwp-3 is an inhibitor of wnt production.wnt signaling proteins, a group of small secreted proteins, are active in tissue homeostasis, embryonic development, as well as tumorigenesis. wnt proteins can bind to the cell surface receptors, initiating a signaling cascade that results in the β-catenin activation of gene transcription.
Biochem/physiol Actions
IWP-3 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). IWP-3 is an inactivator of Porcn function that acts as inhibitors of Wnt production. Studies revealed that IWP-3 induces differentiation of human mesoderm cells to form cardiomyocytes.
in vitro
in previous study, iwp-3 was identified as an inhibitor of wnt production that could regulate in vitro wnt pathway activity with an ic50 value of 40 nm. in addition, iwp-3 was found to be able to inactivate porcupine, a o-acyltransferase for palmitoylating wnt proteins that was critical for the signaling ability and secretion. moreover, iwp-3 at 5 μm was found to block wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 and the scaffold protein dishevelled, resulting in preventing the accumulation of β-catenin [1]. in another study, iwp-3 was applied to promote cardiomyocyte generation from human embryonic stem cells by inhibiting wnt signaling [2].
IC 50
40 nm
References
[1] b. chen, m. e. dodge, w. tang, et al. small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. nature chemical biology 5(2), 100-107 (2009).
[2] e. willems, s. spiering, h. davidovics, et al. small molecule inhibitors of the wnt pathway potently promote cardiomyocytes from human embryonic stem cell derived mesoderm. circulation research 109(4), 360-364 (2011).
IWP-3 Preparation Products And Raw materials
Raw materials
Preparation Products
IWP-3 Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
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- United States
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- 025-58849295 18951903616;
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- 025-68650336
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- China
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- 021-61415566 800-8193336
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- China
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- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
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- China
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- 021-65675885 18964387627
- Fax
- 021-65675885
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- China
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- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
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- 5010
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- 15076683720
- Fax
- 022-23754520
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- China
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- 0519-83246372 13585352506
- Fax
- 0519-83246372
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- China
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- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
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- 1990
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- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32165
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View Lastest Price from IWP-3 manufacturers
- Product
- IWP-3 687561-60-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10
- Product
- IWP-3 687561-60-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-10