Cerdulatinib

ChemicalBook > CAS DataBase List > Cerdulatinib

Product Name: Cerdulatinib
CAS No.: 1198300-79-6
Chemical Name: Cerdulatinib
Synonyms: PRT-062070;CS-1823;PRT2070);Cerdulatinib;Cerdulatinib D5;Cerdulatinib (PRT2070);PRT062070(Cerdulatnib);Cerdulatinib(PRT-062070;PRT 062070 (Cerdulatinib);Cerdulatinib trifluoroacetate salt
CBNumber: CB82715618
Molecular Formula: C20H27N7O3S
Formula Weight: 445.54
MOL File: 1198300-79-6.mol

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Cerdulatinib Property

Melting point:: >211°C (dec.)
Boiling point:: 741.9±70.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 14.17±0.50(Predicted)
color: Light Yellow Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20076
Product name: Cerdulatinib
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 20076
Product name: Cerdulatinib
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 20076
Product name: Cerdulatinib
Purity: ≥98%
Packaging: 25mg
Price: $225
Updated: 2024/03/01

Cayman Chemical

Product number: 20076
Product name: Cerdulatinib
Purity: ≥98%
Packaging: 50mg
Price: $419
Updated: 2024/03/01

TRC

Product number: C273000
Product name: Cerdulatinib(PRT2070)
Packaging: 100mg
Price: $590
Updated: 2021/12/16

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Cerdulatinib Chemical Properties,Usage,Production

Uses

Cerdulatinib (PRT2070), acts as a novel oral and dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Preferentially selects for JAK inhibitors (JAK1 and JAK3 primarily), preventing cytokine mediated signaling and functional responses varying cell types. Potential anti-cancer agent.

Biological Activity

cerdulatinib (prt062070) is a potent and selective inhibitor of syk and jak.[1]the jak/stat cascade, which has been implicated in hematopoiesis and cytokine signaling, is present in humans and flies. worms. the syk/zap70 kinases play an important role in human t and b cell signaling.[3]cerdulatinib can induce apoptosis via down-regulation of mcl1 protein and parp cleavage. through the inhibition of rb phosphorylation and down-regulation of cyclin e,the cerdulatinib can also block g1/s transition and cause cell cycle arrest. further analyses of the cell signaling activities showed that stat3 phosphorylation was sensitive to inhibition by cerdulatinib in abc cell lines while phosphorylation of syk, plcg2, akt and erk is reported to be sensitive to inhibition by cerdulatinib in gcb cell lines.[2]cerdulatinib is effective in rodent models of b-cell lymphoma and autoimmune disease and has exhibited anti-tumor activity in genetically diverse b-cell lymphoma cell lines and is more effective than syk- or jak- selective inhibitors alone.[1]

References

[1] manish patel , pau hamlin, md, etal. , a phase i open-label, multi-dose escalation study of the dual syk/jak inhibitor prt062070 (cerdulatinib) in patients with relapsed/refractory b cell malignancies. blood: 124 (21) ; december 6, 2014.
[2] y. lynn wang, md phd, jiao ma, phd, etal., syk and stat3 are active in diffuse large b-cell lymphoma: activity of cerdulatinib, a dual syk/jak inhibitor. blood: 124 (21) ; december 6, 2014.
[3]morrison dk, murakami ms, cleghon v. protein kinases and phosphatases in the drosophila genome. j cell biol. 2000 jul 24;150(2):f57-62.

Cerdulatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cerdulatinib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cerdulatinib 1198300-79-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cerdulatinib 1198300-79-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Cerdulatinib 1198300-79-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2020-03-05

1198300-79-6, CerdulatinibRelated Search:

PRT062070; PRT2070; PRT-062070; PRT-2070; PRT 062070; PRT 2070

PRT 062070 (Cerdulatinib)

CS-1823

4-(Cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide

Cerdulatinib

PRT-062070

4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide PRT062070

Cerdulatinib(PRT-062070

PRT2070)

Cerdulatinib (PRT2070)

4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

PRT062070(Cerdulatnib)

5-Pyrimidinecarboxamide, 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-

Cerdulatinib trifluoroacetate salt

Cerdulatinib D5

1198300-79-6

C20H27N7O3S

Inhibitors