ChemicalBook > CAS DataBase List > Cerdulatinib

Cerdulatinib

Product Name
Cerdulatinib
CAS No.
1198300-79-6
Chemical Name
Cerdulatinib
Synonyms
PRT-062070;CS-1823;PRT2070);Cerdulatinib;Cerdulatinib D5;Cerdulatinib (PRT2070);PRT062070(Cerdulatnib);Cerdulatinib(PRT-062070;PRT 062070 (Cerdulatinib);Cerdulatinib trifluoroacetate salt
CBNumber
CB82715618
Molecular Formula
C20H27N7O3S
Formula Weight
445.54
MOL File
1198300-79-6.mol
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Cerdulatinib Property

Melting point:
>211°C (dec.)
Boiling point:
741.9±70.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
14.17±0.50(Predicted)
color 
Light Yellow Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20076
Product name
Cerdulatinib
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
20076
Product name
Cerdulatinib
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
20076
Product name
Cerdulatinib
Purity
≥98%
Packaging
25mg
Price
$225
Updated
2024/03/01
Cayman Chemical
Product number
20076
Product name
Cerdulatinib
Purity
≥98%
Packaging
50mg
Price
$419
Updated
2024/03/01
TRC
Product number
C273000
Product name
Cerdulatinib(PRT2070)
Packaging
100mg
Price
$590
Updated
2021/12/16
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Cerdulatinib Chemical Properties,Usage,Production

Uses

Cerdulatinib (PRT2070), acts as a novel oral and dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Preferentially selects for JAK inhibitors (JAK1 and JAK3 primarily), preventing cytokine mediated signaling and functional responses varying cell types. Potential anti-cancer agent.

Biological Activity

cerdulatinib (prt062070) is a potent and selective inhibitor of syk and jak.[1]the jak/stat cascade, which has been implicated in hematopoiesis and cytokine signaling, is present in humans and flies. worms. the syk/zap70 kinases play an important role in human t and b cell signaling.[3]cerdulatinib can induce apoptosis via down-regulation of mcl1 protein and parp cleavage. through the inhibition of rb phosphorylation and down-regulation of cyclin e,the cerdulatinib can also block g1/s transition and cause cell cycle arrest. further analyses of the cell signaling activities showed that stat3 phosphorylation was sensitive to inhibition by cerdulatinib in abc cell lines while phosphorylation of syk, plcg2, akt and erk is reported to be sensitive to inhibition by cerdulatinib in gcb cell lines.[2]cerdulatinib is effective in rodent models of b-cell lymphoma and autoimmune disease and has exhibited anti-tumor activity in genetically diverse b-cell lymphoma cell lines and is more effective than syk- or jak- selective inhibitors alone.[1]

References

[1] manish patel , pau hamlin, md, etal. , a phase i open-label, multi-dose escalation study of the dual syk/jak inhibitor prt062070 (cerdulatinib) in patients with relapsed/refractory b cell malignancies. blood: 124 (21) ; december 6, 2014.
[2] y. lynn wang, md phd, jiao ma, phd, etal., syk and stat3 are active in diffuse large b-cell lymphoma: activity of cerdulatinib, a dual syk/jak inhibitor. blood: 124 (21) ; december 6, 2014.
[3]morrison dk, murakami ms, cleghon v. protein kinases and phosphatases in the drosophila genome. j cell biol. 2000 jul 24;150(2):f57-62.

Cerdulatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cerdulatinib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Cerdulatinib 1198300-79-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cerdulatinib 1198300-79-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Cerdulatinib 1198300-79-6
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2020-03-05

1198300-79-6, CerdulatinibRelated Search:


  • PRT062070; PRT2070; PRT-062070; PRT-2070; PRT 062070; PRT 2070
  • PRT 062070 (Cerdulatinib)
  • CS-1823
  • 4-(Cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide
  • Cerdulatinib
  • PRT-062070
  • 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide PRT062070
  • Cerdulatinib(PRT-062070
  • PRT2070)
  • Cerdulatinib (PRT2070)
  • 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide
  • PRT062070(Cerdulatnib)
  • 5-Pyrimidinecarboxamide, 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-
  • Cerdulatinib trifluoroacetate salt
  • Cerdulatinib D5
  • 1198300-79-6
  • C20H27N7O3S
  • Inhibitors