HG-14-10-04

Product Name: HG-14-10-04
CAS No.: 1356962-34-9
Chemical Name: HG-14-10-04
Synonyms: CS-1175;CS-2526;HG-14-10-04;HG-14-10-04, 10 mM in DMSO;5-chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine;2-Pyrimidinamine, 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-;Anaplastic lymphoma kinase (ALK),HG 14 10 04,Anaplastic lymphoma kinase,ErbB-1,Inhibitor,EGFR,anticancer,HG141004,CD246,inhibit,HER1,Cluster of differentiation 246,Epidermal growth factor receptor,ALK tyrosine kinase receptor
CBNumber: CB82715638
Molecular Formula: C29H34ClN7O
Formula Weight: 532.08
MOL File: 1356962-34-9.mol

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HG-14-10-04 Property

Boiling point:: 761.1±70.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 13.3 mg/mL (25.00 mM; Need ultrasonic and warming)
form: Powder
pka: 14.62±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22984
Product name: HG-14-10-04
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 22984
Product name: HG-14-10-04
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 22984
Product name: HG-14-10-04
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 22984
Product name: HG-14-10-04
Purity: ≥98%
Packaging: 25mg
Price: $745
Updated: 2024/03/01

ChemScene

Product number: CS-3257
Product name: HG-14-10-04
Purity: 98.83%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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HG-14-10-04 Chemical Properties,Usage,Production

Uses

HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer[1][2].

Definition

ChEBI: 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine is a member of piperidines.

IC 50

EGFR^LR/TM: 15.6 nM (IC₅₀); EGFR^19del/TM/CS: 22.6 nM (IC₅₀); EGFR^LR/TM/CS: 124.5 nM (IC₅₀); ALK: 20 nM (IC₅₀)

References

[1] U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
[2] Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. DOI:10.1021/acs.jmedchem.2c00168

HG-14-10-04 Preparation Products And Raw materials

Raw materials

Preparation Products

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HG-14-10-04 Suppliers

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1356962-34-9, HG-14-10-04Related Search:

[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

HG-14-10-04

5-chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

CS-2526

CS-1175

2-Pyrimidinamine, 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-

Anaplastic lymphoma kinase (ALK),HG 14 10 04,Anaplastic lymphoma kinase,ErbB-1,Inhibitor,EGFR,anticancer,HG141004,CD246,inhibit,HER1,Cluster of differentiation 246,Epidermal growth factor receptor,ALK tyrosine kinase receptor

HG-14-10-04, 10 mM in DMSO

1356962-34-9