ChemicalBook > CAS DataBase List > NIBR189

NIBR189

Product Name: NIBR189
CAS No.: 1599432-08-2
Chemical Name: NIBR189
Synonyms: CS-1583;NIBR189;NIBR189 ，S0183;NIBR-189; NIBR 189;NIBR189, 10 mM in DMSO;(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one;(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one;(2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one;2-Propen-1-one, 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-, (2E)-;Inhibitor,mice,small molecule,NIBR 189,autoimmune diseases,autoimmune,EBI2/GPR183,NIBR189,U937,NIBR-189,G protein,inhibit,migration
CBNumber: CB82715658
Molecular Formula: C21H21BrN2O3
Formula Weight: 429.31
MOL File: 1599432-08-2.mol

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NIBR189 Property

Boiling point:: 639.7±55.0 °C(Predicted)
Density: 1.403±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: -0.86±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1981
Product name: NIBR189
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1981
Product name: NIBR189
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $305.2
Updated: 2025/07/31

Cayman Chemical

Product number: 18792
Product name: NIBR189
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18792
Product name: NIBR189
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18792
Product name: NIBR189
Purity: ≥95%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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NIBR189 Chemical Properties,Usage,Production

Uses

(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases.

Biological Activity

nibr189 is a small molecule antagonist of the epstein-barr virus-induced gene 2 (ebi2; gpr183) receptor with ic50 of 16 nm(binding) and 11 nm (functional).

in vivo

1.19Pharmacokinetic Properties of NIBR189 in Mice^[1].

	Mice IV 1 mg/kg	Mice PO 3 mg/kg
CL (μL/min/mg)	16
t_1/2 (h)	1.1
V_ss (L/kg)	1.4
AUC (nmol·h/L)	2435	3608
C_max (nmol/L)		835
t_max (h)		1
F (%)		49

storage

Store at +4°C

NIBR189 Preparation Products And Raw materials

Raw materials

Preparation Products

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1599432-08-2, NIBR189Related Search:

NIBR189

(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one

(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one

CS-1583

NIBR-189; NIBR 189

(2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one

2-Propen-1-one, 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-, (2E)-

Inhibitor,mice,small molecule,NIBR 189,autoimmune diseases,autoimmune,EBI2/GPR183,NIBR189,U937,NIBR-189,G protein,inhibit,migration

NIBR189, 10 mM in DMSO

NIBR189 ，S0183

1599432-08-2

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