ON 146040

Product Name: ON 146040
CAS No.: 1404231-34-0
Chemical Name: ON 146040
Synonyms: ON 146040;ON 146040, 10 mM in DMSO;2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-7-(4-nitrobenzylidene)-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one;(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one;5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]-
CBNumber: CB82715663
Molecular Formula: C24H23N7O3S
Formula Weight: 489.55
MOL File: 1404231-34-0.mol

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ON 146040 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31003603
Product name: ON146040
Purity: 98+%
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Crysdot

Product number: CD31003603
Product name: ON146040
Purity: 98+%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

Crysdot

Product number: CD31003603
Product name: ON146040
Purity: 98+%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Crysdot

Product number: CD31003603
Product name: ON146040
Purity: 98+%
Packaging: 100mg
Price: $1470
Updated: 2021/12/16

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ON 146040 Chemical Properties,Usage,Production

Uses

ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).

IC 50

PI3Kα: 14 nM (IC₅₀); PI3Kδ: 20 nM (IC₅₀); PI3Kγ: 1 μM (IC₅₀); PI3Kβ: 3 μM (IC₅₀)

References

[1] Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL.

ON 146040 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON 146040 Suppliers

China 23 United States 6 Global 29

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

1404231-34-0, ON 146040Related Search:

ON 146040

(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one

5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]-

2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-7-(4-nitrobenzylidene)-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one

ON 146040, 10 mM in DMSO

1404231-34-0

C24H23N7O3S