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Morinidazole

Product Name
Morinidazole
CAS No.
92478-27-8
Chemical Name
Morinidazole
Synonyms
Morinidazole;Morinidazole, 10 mM in DMSO;Morpholinenidazole impurity H;1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-;alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
CBNumber
CB82716291
Molecular Formula
C11H18N4O4
Formula Weight
270.29
MOL File
92478-27-8.mol
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Morinidazole Property

Boiling point:
521.4±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (369.97 mM)
pka
14.14±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5058
Product name
Morinidazole
Purity
>98.0%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-5058
Product name
Morinidazole
Purity
>98.0%
Packaging
10mg
Price
$600
Updated
2021/12/16
Crysdot
Product number
CD31000234
Product name
Morinidazole
Purity
98+%
Packaging
5mg
Price
$245
Updated
2021/12/16
Crysdot
Product number
CD31000234
Product name
Morinidazole
Purity
98+%
Packaging
10mg
Price
$350
Updated
2021/12/16
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Morinidazole Chemical Properties,Usage,Production

Description

Morinidazole (迈灵达®), discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.

Uses

Morinidazole is a useful research chemical compound used as a microbial drug against Trichomoniasis, a non-viral sexually transmitted disease.

Synthesis

The strategy to prepare morinidazole, which exists as a racemate, overlaps with that of ornidazole. Commercially available epichlorohydrin (176) was reacted with commercial 2-methyl-5-nitro-1H-imidazole (175) to provide ornidazole 177 in 51% yield. Next, epoxide 178 was obtained in 84% through the treatment of ornidazole 177 with TBAF in aqueous sodium hydroxide. Subsequently, the ring of epoxide 178 was opened with the treatment of morpholine (179) to afford morinidazole (XX) in 75% yield.

Morinidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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92478-27-8, MorinidazoleRelated Search:


  • Morinidazole
  • alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
  • 4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-
  • 1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol
  • Morpholinenidazole impurity H
  • Morinidazole, 10 mM in DMSO
  • 92478-27-8