ChemicalBook > CAS DataBase List > Morinidazole

Morinidazole

Product Name: Morinidazole
CAS No.: 92478-27-8
Chemical Name: Morinidazole
Synonyms: Morinidazole;Morpholine nitroimidazole;Morinidazole, 10 mM in DMSO;Morpholinenidazole impurity H;1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-;alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
CBNumber: CB82716291
Molecular Formula: C11H18N4O4
Formula Weight: 270.29
MOL File: 92478-27-8.mol

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Morinidazole Property

Boiling point:: 521.4±50.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (369.97 mM)
pka: 14.14±0.20(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C11H18N4O4/c1-9-12-6-11(15(17)18)14(9)8-10(16)7-13-2-4-19-5-3-13/h6,10,16H,2-5,7-8H2,1H3
InChIKey: GAZGHCHCYRSPIV-UHFFFAOYSA-N
SMILES: C(N1C(=NC=C1N(=O)=O)C)C(O)CN1CCOCC1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5058
Product name: Morinidazole
Purity: >98.0%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5058
Product name: Morinidazole
Purity: >98.0%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Crysdot

Product number: CD31000234
Product name: Morinidazole
Purity: 98+%
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Crysdot

Product number: CD31000234
Product name: Morinidazole
Purity: 98+%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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Morinidazole Chemical Properties,Usage,Production

Description

Morinidazole, discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.

Uses

Morinidazole is a useful research chemical compound used as a microbial drug against Trichomoniasis, a non-viral sexually transmitted disease.

Synthesis

The strategy to prepare morinidazole, which exists as a racemate, overlaps with that of ornidazole. Commercially available epichlorohydrin (176) was reacted with commercial 2-methyl-5-nitro-1H-imidazole (175) to provide ornidazole 177 in 51% yield. Next, epoxide 178 was obtained in 84% through the treatment of ornidazole 177 with TBAF in aqueous sodium hydroxide. Subsequently, the ring of epoxide 178 was opened with the treatment of morpholine (179) to afford morinidazole (XX) in 75% yield.

in vivo

Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC₅₀s of 20 mg/kg and 25 mg/kg, respectively^[2].
Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice^[3].
Pharmacokinetic parameters of Morinidazole in control and 5/6 nephrectomized (Nx) rats^[3]

Group	C_max (μg/mL)	T_max (h)	T_1/2 (h)	AUC_0-t (μg·h/mL)	AUC_0-∞ (μg·h/mL)	CL (mL/h/kg)	V_ss (mL/kg)	MRT (h)
Control rats	48.2	0.08	1.16	87.2	87.3	582	805	1.39
5/6 Nx rats	53.2	0.08	1.32	91.2	91.3	552	891	1.62

Intravenous injection; 50 mg/kg Morinidazole; Blood samples were collected from retro-orbital venous plexus before the dose (0 hours), at 5, 15, and 30 minutes, and at 1, 2, 4, 6, 8, and 12 hours after the dose.

Animal Model:	Renal failure model in SD rats (180-220 g)^[3]
Dosage:	50 mg/kg
Administration:	Intravenous injection; sacrificed rats at 0.25, 0.75, and 1.50 hours after dose administration
Result:	Increased plasma exposures slightly compared with control.

Morinidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Morinidazole manufacturers

Chongqing Soarwin Technology Co., Ltd

Product: Morinidazole 92478-27-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-11

92478-27-8, MorinidazoleRelated Search:

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92478-27-8