Ferric carboxymaltose
- Product Name
- Ferric carboxymaltose
- CAS No.
- 9007-72-1
- Chemical Name
- Ferric carboxymaltose
- Synonyms
- Ferinject;Injectafer;Ferric carboxymahose;Injectafer USP/EP/BP;Ferric Carboxymaltos;Iron Dextri-Maltose;Ferric carboxymaltose;Ferric Carboxymaltose Injectafer
- CBNumber
- CB82717081
- Molecular Formula
- C39H63FeO39
- Formula Weight
- 1211.73912
- MOL File
- 9007-72-1.mol
Ferric carboxymaltose Property
- InChIKey
- CRTIFGUDJMSNSV-SJEGEKMXNA-K
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
Ferric carboxymaltose Chemical Properties,Usage,Production
Mechanism of action
Ferric carboxymaltose is a macromolecular ferric hydroxide carbohydrate complex, which allows for controlled delivery of iron within the cells of the reticuloendothelial system and subsequent delivery to the iron-binding proteins ferritin and transferrin, with minimal risk of release of large amounts of ionic iron in the serum. Intravenous administration of ferric carboxymaltose results in transient elevations in serum iron, serum ferritin and transferrin saturation, and, ultimately, in the correction of haemoglobin levels and replenishment of depleted iron stores.
Clinical Use
Ferric carboxymaltose complex:Treatment of iron deficiency anaemia (when oral treatment is ineffective or contraindicated)
Side effects
Ferric carboxymaltose was well tolerated, with most drug-related adverse events being mild to moderate in severity. Commonly reported drug-related adverse events included headache, dizziness, nausea, abdominal pain, constipation, diarrhoea, rash and injection site reactions.
The incidence of drug-related adverse events in patients receiving intravenous ferric carboxymaltose was generally similar to that in patients receiving oral ferrous sulfate. In general, rash and local injection-site reactions were more common with ferric carboxymaltose, whereas gastrointestinal adverse events were more frequent with ferrous sulfate. In patients with chronic kidney disease undergoing haemodialysis, a lower proportion of ferric carboxymaltose than iron sucrose recipients experienced at least one drug-related adverse event.
Drug interactions
Potentially hazardous interactions with other drugs Dimercaprol: avoid concomitant use. Oral iron: reduced absorption
Metabolism
Most absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin; the remainder is contained within the storage forms, ferritin or haemosiderin, or as myoglobin, with smaller amounts occurring in haem-containing enzymes or in plasma bound to transferrin. Only very small amounts of iron are excreted as the majority released after the destruction of the haemoglobin molecule is re-used.
Ferric carboxymaltose Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ferric carboxymaltose manufacturers
- Product
- Ferric carboxymaltose 9007-72-1
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1t
- Release date
- 2023-07-11
- Product
- Ferric carboxymaltose 9007-72-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09
- Product
- Ferric Carboxymahose 9007-72-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 0.99
- Supply Ability
- 100 kg
- Release date
- 2024-01-19