BMH21
- Product Name
- BMH21
- CAS No.
- 896705-16-1
- Chemical Name
- BMH21
- Synonyms
- BMH21;CS-1749;BMH-21, >98%;BMH 21;BMH21;BMH-21 ，S7718;BMH21 USP/EP/BP;BMH-21, 10 mM in DMSO;BMH-21/896705-16-1/98%;RNA Polymerase I Inhibitor II, BMH-21;N-[2-(Dimethylamino)ethyl]-12-oxo-5,13-diazatetracene-4-carboxamide
- CBNumber
- CB82728814
- Molecular Formula
- C21H20N4O2
- Formula Weight
- 360.41
- MOL File
- 896705-16-1.mol
BMH21 Property
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble1mg/mL, clear (warmed)
- pka
- 7.90±0.20(Predicted)
- form
- powder
- color
- light yellow to dark yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1183
- Product name
- BMH-21
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $124
- Updated
- 2025/07/31
- Product number
- SML1183
- Product name
- BMH-21
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $475
- Updated
- 2025/07/31
- Product number
- 22282
- Product name
- BMH-21
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 22282
- Product name
- BMH-21
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 22282
- Product name
- BMH-21
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $239
- Updated
- 2024/03/01
BMH21 Chemical Properties,Usage,Production
Uses
BMH-21 has been used in cell culture.
General Description
BMH-21 is a planar heterocyclic small molecule DNA intercalator.
Biochem/physiol Actions
BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.
Synthesis
108-00-9
63127-04-8
896705-16-1
Method A: Synthesis of amide analogs (4). Synthesis of N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide. 12-Oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxylic acid (50 mg, 0.17 mmol) and TBTU (82.9 mg, 0.26 mmol) were dissolved in DMF (1 mL) and DbEA (90 μL, 0.52 mmol) was added. After stirring for 15 min at room temperature, N,N-dimethylethylenediamine (28.4 μL, 0.26 mmol) was added and stirring was continued for 16 hours. The reaction mixture was poured into 100 mL of cold water with stirring, and the solid was collected by filtration and dried under vacuum to afford the target product N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide (36 mg, 0.10 mmol, 58.0% yield) as a yellow solid.1H NMR (400 MHz , DMSO-d6) δ ppm 11.50 (br.s, 1H), 9.10 (s, 1H), 8.91 (d, J=5.81 Hz, 1H), 8.55 (d, J=5.56 Hz, 1H), 8.28-8.34 (m, 2H), 8.12 (d, J=8.34 Hz, 1H), 7.73 (t, J=7.45 Hz , 1H), 7.61 (t, J=7.33 Hz, 1H), 7.05 (t, J=7.07 Hz, 1H), 3.56 (d, J=5.05 Hz, 2H), 2.59 (t, J=5.94 Hz, 2H), 2.40 (s, 6H).1H NMR (400 MHz, CDCl3) δ ppm 11.70 (br.s. 1H), 9.10 (s, 1H), 8.94 (dd, J=7.33,1.77 Hz, 1H), 8.73 (dd, J=6.82,1.77 Hz, 1H), 8.29 (s, 1H), 8.12 (d, J=8.59 Hz, 1H), 8.00 (d, J=8.34 Hz, 1H), 7.66 (t, J= 7.58 Hz, 1H), 7.52-7.60 (m, 1H), 6.89 (t, J=7.07 Hz, 1H), 3.66-3.77 (m, 2H), 2.71 (t, J=6.06 Hz, 2H), 2.49 (s, 6H). ms [M+1]=361.
in vivo
BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo[2].
| Animal Model: | 6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft[2] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection, daily, for 6 days |
| Result: | Significantly inhibited HCT116 colon cancer tumor growth. |
storage
Store at -20°C
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4950 - 4961
[2] Patent: WO2015/143293, 2015, A1. Location in patent: Paragraph 0084
BMH21 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BMH21 manufacturers
- Product
- BMH21 896705-16-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05