ZLN-024

Product Name: ZLN-024
CAS No.: 723249-01-2
Chemical Name: ZLN-024
Synonyms: ZLN024;ZLN-024;ZLN-024 (ZLN024);ZLN024, 10 mM in DMSO;2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine;2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine;Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-;Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024
CBNumber: CB82729381
Molecular Formula: C13H13BrN2OS
Formula Weight: 325.22
MOL File: 723249-01-2.mol

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ZLN-024 Property

Boiling point:: 443.3±35.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 0.12±0.33(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0900
Product name: ZLN024
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $65.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0900
Product name: ZLN024
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $424
Updated: 2022/05/15

Cayman Chemical

Product number: 21644
Product name: ZLN024
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 21644
Product name: ZLN024
Purity: ≥98%
Packaging: 10mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 21644
Product name: ZLN024
Purity: ≥98%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

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ZLN-024 Chemical Properties,Usage,Production

Uses

ZLN024 is a useful chemical reagent.

Biological Activity

ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.

in vivo

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased^[1].

IC 50

AMPK α2β2γ1: 0.13 μM (EC₅₀); AMPK α1β1γ1: 0.42 μM (EC₅₀); AMPK α2β1γ1: 0.95 μM (EC₅₀)

ZLN-024 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZLN-024 Suppliers

China 44 The Netherlands 1 United Kingdom 1 United States 10 Global 56

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
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LETOPHARM LIMITED

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Email: sales@letopharm.com
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Pharmacodia (Beijing) Co.,Ltd

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Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai SuperLan Chemcial Technique Centre

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Amadis Chemical Company Limited

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723249-01-2, ZLN-024Related Search:

ZLN-024 hydrochloride

2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine

ZLN024

ZLN-024

2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine

Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-

Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024

ZLN024, 10 mM in DMSO

ZLN-024 (ZLN024)

723249-01-2