ChemicalBook > CAS DataBase List > ZLN-024

ZLN-024

Product Name
ZLN-024
CAS No.
723249-01-2
Chemical Name
ZLN-024
Synonyms
ZLN024;ZLN-024;ZLN-024 (ZLN024);ZLN024, 10 mM in DMSO;2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine;2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine;Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-;Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024
CBNumber
CB82729381
Molecular Formula
C13H13BrN2OS
Formula Weight
325.22
MOL File
723249-01-2.mol
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ZLN-024 Property

Boiling point:
443.3±35.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
0.12±0.33(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0900
Product name
ZLN024
Purity
≥98% (HPLC)
Packaging
5mg
Price
$65.8
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0900
Product name
ZLN024
Purity
≥98% (HPLC)
Packaging
25mg
Price
$424
Updated
2022/05/15
Cayman Chemical
Product number
21644
Product name
ZLN024
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
21644
Product name
ZLN024
Purity
≥98%
Packaging
10mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
21644
Product name
ZLN024
Purity
≥98%
Packaging
25mg
Price
$330
Updated
2024/03/01
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ZLN-024 Chemical Properties,Usage,Production

Uses

ZLN024 is a useful chemical reagent.

Biological Activity

ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.

in vivo

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1].

IC 50

AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50)

ZLN-024 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZLN-024 Suppliers

China 44 The Netherlands 1 United Kingdom 1 United States 10 Global 56
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58

723249-01-2, ZLN-024Related Search:

ZLN-024 hydrochloride

  • 2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine
  • ZLN024
  • ZLN-024
  • 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
  • Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-
  • Inhibitor,AMPK,AMP-activated protein kinase,inhibit,ZLN024,ZLN 024,ZLN-024
  • ZLN024, 10 mM in DMSO
  • ZLN-024 (ZLN024)
  • 723249-01-2