ChemicalBook > CAS DataBase List > BRD73954

BRD73954

Product Name: BRD73954
CAS No.: 1440209-96-0
Chemical Name: BRD73954
Synonyms: CS-1777;BRD73954;BRD-73954;BRD 73954;BRD73954, 10 mM in DMSO;N1-hydroxy-N3-phenethylisophthalamide;N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide;1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide;N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
CBNumber: CB82730826
Molecular Formula: C16H16N2O3
Formula Weight: 284.31
MOL File: 1440209-96-0.mol

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BRD73954 Property

Melting point:: 172-175oC
Density: 1.245±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 8.56±0.10(Predicted)
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1361
Product name: BRD73954
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $129
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1361
Product name: BRD73954
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $513
Updated: 2022/05/15

Cayman Chemical

Product number: 16919
Product name: BRD73954
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 16919
Product name: BRD73954
Purity: ≥95%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 16919
Product name: BRD73954
Purity: ≥95%
Packaging: 10mg
Price: $632
Updated: 2024/03/01

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BRD73954 Chemical Properties,Usage,Production

Description

BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC₅₀s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC₅₀s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.

Uses

BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells.

IC 50

HDAC6: 0.036 μM (IC₅₀); HDAC8: 0.12 μM (IC₅₀); HDAC2: 9 μM (IC₅₀); HDAC1: 12 μM (IC₅₀); HDAC3: 23 μM (IC₅₀)

storage

Store at +4°C

References

[1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820.

BRD73954 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BRD73954 manufacturers

Career Henan Chemical Co

Product: BRD73954 1440209-96-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1440209-96-0, BRD73954Related Search:

N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide

BRD73954

N1-hydroxy-N3-phenethylisophthalamide

N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954

BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide

BRD-73954;BRD 73954

CS-1777

1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-

BRD73954, 10 mM in DMSO

3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide

1440209-96-0

Inhibitors