ChemicalBook > CAS DataBase List > Syntelin
Syntelin
- Product Name
- Syntelin
- CAS No.
- 438481-33-5
- Chemical Name
- Syntelin
- Synonyms
- Syntelin;2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid;Acetic acid, 2-[[5-[[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-;2-[[5-[(4-amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetic acid
- CBNumber
- CB82731146
- Molecular Formula
- C21H20N6O2S3
- Formula Weight
- 484.62
- MOL File
- 438481-33-5.mol
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Syntelin Property
- Boiling point:
- 832.2±75.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- pka
- 3.00±0.10(Predicted)
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Syntelin Chemical Properties,Usage,Production
Description
Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.
Syntelin Preparation Products And Raw materials
Raw materials
Preparation Products
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Syntelin Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19699
- Advantage
- 58