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PHA-767491 (hydrochloride)

Product Name
PHA-767491 (hydrochloride)
CAS No.
942425-68-5
Chemical Name
PHA-767491 (hydrochloride)
Synonyms
PHA-767491 HCl ，S2742;CAY-10572 HYDROCHLORIDE;PHA-767491A hydrochloride;PHA-767491 hydrochloride, 10 mM in DMSO;CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor;2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
CBNumber
CB82735533
Molecular Formula
C12H12ClN3O
Formula Weight
249.7
MOL File
942425-68-5.mol
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PHA-767491 (hydrochloride) Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO:20.0(Max Conc. mg/mL);80.1(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18218
Product name
PHA-767491 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
18218
Product name
PHA-767491 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
18218
Product name
PHA-767491 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
18218
Product name
PHA-767491 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$324
Updated
2024/03/01
ChemScene
Product number
CS-3865
Product name
PHA 767491 hydrochloride
Purity
99.91%
Packaging
50mg
Price
$355
Updated
2021/12/16
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PHA-767491 (hydrochloride) Chemical Properties,Usage,Production

Uses

PHA 767491 Hydrochloride (cas# 942425-68-5) is a useful research chemical used in the synthesis of heteroaryl-substituted pyrrolopyridinones and analogs as cdc7 kinase inhibitors and potential antitumor agents.

in vivo

PHA-767491 decreases Chk1 phosphorylation and increases in situ cell apoptosis in tumor tissues sectioned from nude mice HCC xenografts[2].

IC 50

CDK9: 34 nM (IC50); CDK2: 240 nM (IC50); CDK1: 250 nM (IC50); CDK5: 460 nM (IC50); GSK3-β: 220 nM (IC50); Mk2: 470 nM (IC50); Plk1: 980 nM (IC50); Chk2: 1100 nM (IC50)

storage

Desiccate at RT

PHA-767491 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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PHA-767491 (hydrochloride) Suppliers

China 59 India 1 United Kingdom 1 United States 10 Global 71
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

942425-68-5, PHA-767491 (hydrochloride)Related Search:

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  • CAY-10572 HYDROCHLORIDE
  • 2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
  • PHA-767491A hydrochloride
  • CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor
  • PHA-767491 hydrochloride, 10 mM in DMSO
  • PHA-767491 HCl ，S2742
  • 942425-68-5