ChemicalBook > CAS DataBase List > 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione

6-(octylaMino)pyriMidine-2,4(1H,3H)-dione

Product Name: 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
CAS No.: 83797-69-7
Chemical Name: 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
Synonyms: 6-OAU;CS-2658;GTPL5846;6-OAU, >98%;6-OAU ，S0208;GTPL5846, >98%;6-OAU(GTPL5846);GTPL-5846 (6-OAU);6-OAU, 10 mM in DMSO;6-n-Octylaminouracil )
CBNumber: CB82736888
Molecular Formula: C12H21N3O2
Formula Weight: 239.31
MOL File: 83797-69-7.mol

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6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Property

storage temp.: Store at -20°C
solubility: ≤0.25mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form: crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17687
Product name: 6-OAU
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17687
Product name: 6-OAU
Purity: ≥98%
Packaging: 5mg
Price: $388
Updated: 2024/03/01

Cayman Chemical

Product number: 17687
Product name: 6-OAU
Purity: ≥98%
Packaging: 10mg
Price: $638
Updated: 2024/03/01

ApexBio Technology

Product number: C5367
Product name: 6-OAU
Packaging: 10mg
Price: $677
Updated: 2021/12/16

ApexBio Technology

Product number: C5367
Product name: 6-OAU
Packaging: 1mg
Price: $90
Updated: 2021/12/16

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6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Description

GPR84 is a Gα_i protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC₅₀ = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC₅₀ = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.

Uses

6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].

in vitro

a previous study identified 6-oau as a surrogate agonist for gpr84. it was found that 6-oau and potential ligands were able to stimulate [(35)s]gtp binding and accumulate phosphoinositides in a gpr84-dependent manner. moreover, 6-oau could internalize gpr84-egfp from the cell surface. in addition, results showed that both 6-oau and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (pmns) and macrophages and amplify lps-stimulated production of the proinflammatory cytokine il-8 from pmns and tnfα from macrophages [1].

in vivo

animal study found that the iv injection of 6-oau was able to raise the blood cxcl1 level in rats. in addition, the inoculation of 6-oau into the rat air pouch could accumulate pmns and macrophages in the site [1].

IC 50

ERK

References

[1] suzuki, m. ,takaishi, s.,nagasaki, m., et al. medium-chain fatty acid-sensing receptor, gpr84, is a proinflammatory receptor. the journal of biological chemisty 288(15), 10684-10691 (2013).

6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione manufacturers

Career Henan Chemical Co

Product: 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione 83797-69-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

83797-69-7, 6-(octylaMino)pyriMidine-2,4(1H,3H)-dioneRelated Search:

6-(octylaMino)pyriMidine-2,4(1H,3H)-dione

GTPL 5846;GTPL5846;6-OAU;GTPL-5846

CS-2658

6-OAU, >98%

GTPL5846, >98%

GTPL5846

GTPL-5846 (6-OAU)

6-OAU

6-(Octylamino)-2,4(1H,3H)-pyrimidinedione

6-OAU(GTPL5846)

2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)-

G protein coupled receptor 84,Inhibitor,IL-8,Sf9,ERK,HEK293,PMN,TNF-α,Lauric acid,MAPKs,U937,GPR84,inflammation,GTPL 5846,B. abortus,Extracellular signal regulated kinases,6 OAU,Cytokines,macrophage,GTPL-5846,6-OAU,6OAU,proinflammatory cytokine,G protein-coupled receptor,GTPγS,chemotaxis,rat air pouch model,inhibit

6-OAU, 10 mM in DMSO

6-n-Octylaminouracil )

6-OAU ，S0208

83797-69-7

Inhibitors