6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Product Name
- 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- CAS No.
- 1446507-38-5
- Chemical Name
- 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Synonyms
- Enasidenib Intermediate 2;6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione;3-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione;1,3,5-Triazine-2,4(1H,3H)-dione, 6-[6-(trifluoromethyl)-2-pyridinyl]-
- CBNumber
- CB82737597
- Molecular Formula
- C9H5F3N4O2
- Formula Weight
- 258.16
- MOL File
- 1446507-38-5.mol
6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione Property
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.09±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1985EB
- Product name
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Packaging
- 250mg
- Price
- $177
- Updated
- 2021/12/16
- Product number
- 1985EB
- Product name
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Packaging
- 1g
- Price
- $357
- Updated
- 2021/12/16
- Product number
- 1446507385
- Product name
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Packaging
- 1g
- Price
- $666.6
- Updated
- 2021/12/16
- Product number
- 1446507385
- Product name
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Packaging
- 5g
- Price
- $1960.2
- Updated
- 2021/12/16
- Product number
- A239533
- Product name
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Synthesis
108-19-0
155377-05-2
1446507-38-5
1. Methyl 6-(trifluoromethyl)pyridinecarboxylate (50 g, 244 mmol, 1.0 eq.) and urea condensate (30.2 g, 293 mmol, 1.20 eq.) were dissolved in 750 mL of ethanol and stirred for 10-20 min at 30-35 °C. 2. titanium tetraethoxide (Ti(OEt)4, 27.8 g, 122 mmol, 0.5 eq.) was added to the reaction mixture and stirring was continued at 30-35 °C. 3. 350 g of an ethanol solution of 19% wt sodium ethanol (978 mmol, 4.0 eq.) was added slowly and dropwise, then the reaction mixture was heated to 55-65 °C and maintained for 3 hours. 4. Upon completion of the reaction, the reaction mixture was concentrated, cooled to room temperature and diluted with 700 mL of water. 5. pH was adjusted to 1 with concentrated hydrochloric acid solution, 700 mL of dichloromethane (DCM) was added, and the slurry was stirred at 20-30 °C for 5-7 hours. 6. Collect the solid by filtration and wash it sequentially with 6N hydrochloric acid twice, water twice and DCM once. 7. The wet filter cake was dried under vacuum at 50-60 °C to afford 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione as a white solid (45.0 g, 174 mmol, 71% yield).
References
[1] Patent: WO2017/24134, 2017, A1. Location in patent: Paragraph 0073; 0075; 0079; 0080; 0082
[2] Patent: EP3330258, 2018, A1. Location in patent: Paragraph 0079-0080
[3] Patent: US2015/18328, 2015, A1. Location in patent: Paragraph 0722-0723
[4] Patent: WO2015/3640, 2015, A1. Location in patent: Page/Page column 156; 157
[5] Patent: WO2015/18060, 2015, A1. Location in patent: Page/Page column 48-49
6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione Preparation Products And Raw materials
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View Lastest Price from 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione manufacturers
- Product
- 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione 1446507-38-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione 1446507-38-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-09