7-hydroxyquinoline-3-carboxylic acid

7-hydroxyquinoline-3-carboxylic acid Property

Melting point:

>260 °C

Boiling point:

426.7±30.0 °C(Predicted)

Density 

1.480±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.34±0.30(Predicted)

Appearance

Light yellow to yellow Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

7-hydroxyquinoline-3-carboxylic acid Chemical Properties,Usage,Production

Synthesis

Step E. Synthesis of 7-hydroxyquinoline-3-carboxylic acid. Ethyl 7-methoxyquinoline-3-carboxylate (7.03 g, 30.4 mmol) was dissolved in 48% aqueous hydrobromic acid (150 mL) and heated to reflux at 105 °C for 88.5 hours. After completion of the reaction, it was cooled to room temperature and the precipitate precipitated was collected by filtration to afford the title compound 7-hydroxyquinoline-3-carboxylic acid as a brown solid (5.2 g, 90% yield). 1H NMR (400 MHz, DMSO-d6) δ 12.05-11.67 (m, 1H), 9.49 (d, J = 2.0 Hz, 1H), 9.43 (s, 1H), 8.39 (d, J = 9.8 Hz, 1H), 7.55-7.51 (m, 2H). Mass spectrum (ESI) [M + H]+ m/z = 190.2.

References

[1] Patent: US2014/275548, 2014, A1. Location in patent: Paragraph 0363