ChemicalBook > CAS DataBase List > 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
Uses- Product Name
- 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
- CAS No.
- 1016228-01-5
- Chemical Name
- 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
- Synonyms
- EOS-60946;1-(6-Bromo-3-fluoro-2-pyridyl)ethanone;1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone;Ethanone, 1-(6-bromo-3-fluoro-2-pyridinyl)-;1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one
- CBNumber
- CB82742368
- Molecular Formula
- C7H5BrFNO
- Formula Weight
- 218.02
- MOL File
- 1016228-01-5.mol
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1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone Property
- Boiling point:
- 251.8±40.0 °C(Predicted)
- Density
- 1.619±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.19±0.10(Predicted)
- Appearance
- Light brown to brown Solid
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B803518
- Product name
- 1-(6-Bromo-3-fluoropyridin-2-yl)ethan-1-one
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC421197
- Product name
- 1-(6-Bromo-3-fluoropyridin-2-yl)ethanone
- Purity
- 97%
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
AK Scientific
- Product number
- 6713DP
- Product name
- 1-(6-Bromo-3-fluoropyridin-2-yl)ethanone
- Packaging
- 250mg
- Price
- $229
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC421197
- Product name
- 1-(6-Bromo-3-fluoropyridin-2-yl)ethanone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $256
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC421197
- Product name
- 1-(6-Bromo-3-fluoropyridin-2-yl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $494
- Updated
- 2021/12/16
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1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone Chemical Properties,Usage,Production
Uses
1-(6-bromo-3-fluoropyridin-2-yl)ethyl ketone is a ketone organic compound that can be used as a biochemical reagent.
Synthesis
1403468-45-0
1016228-01-5
General procedure for the synthesis of 1-(6-bromo-3-fluoropyridin-2-yl)ethanol from 1-(6-bromo-3-fluoropyridin-2-yl)ethanone: 8.74 g (39.7 mmol) of 1-(6-bromo-3-fluoropyridin-2-yl)ethanol was dissolved in 175 mL of dichloromethane at room temperature, followed by the addition of 21.4 g (99.0 mmol) of chloro chromic acid pyridinium and 7.50 g of diatomaceous earth. The reaction mixture was stirred at room temperature for 25 hours before being filtered through the diatomaceous earth and washed with dichloromethane. The dichloromethane in the filtrate was concentrated and the residue was purified by fast chromatography (using 220 g of silica gel, eluent 0 to 10% hexane solution of ethyl acetate) to afford the target product 1-(6-bromo-3-fluoropyridin-2-yl)ethanone (6.82 g, 79% yield).LCMS (condition A): retention time t R = 2.11 min, mass-to-charge ratio m/e = 218 (M + H).
References
[1] Patent: WO2012/139425, 2012, A1. Location in patent: Page/Page column 120
[2] Patent: WO2015/187437, 2015, A1. Location in patent: Page/Page column 57
1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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