ChemicalBook > CAS DataBase List > AF38469

AF38469

Product Name: AF38469
CAS No.: 1531634-31-7
Chemical Name: AF38469
Synonyms: CS-2561;AF38469;AF38469 ，S7478;AF38469 (AF-38469);AF38469, 10 mM in DMSO;inhibit,AF 38469,Neurotensin Receptor,Inhibitor,AF38469;2-[(6-Methyl-2-pyridyl)carbamoyl]-5-(trifluoromethyl)benzoic Acid;2-((6-Methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid;Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-
CBNumber: CB82744892
Molecular Formula: C15H11F3N2O3
Formula Weight: 324.25
MOL File: 1531634-31-7.mol

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AF38469 Property

Boiling point:: 392.3±42.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Soluble; Ethanol: Soluble
form: A solid
pka: 2.83±0.36(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4149
Product name: AF38469
Purity: 99.28%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-4149
Product name: AF38469
Purity: 99.28%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-4149
Product name: AF38469
Purity: 99.28%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611584
Product name: AF38469
Packaging: 250mg
Price: $2395.3
Updated: 2021/12/16

ChemScene

Product number: CS-4149
Product name: AF38469
Purity: 99.28%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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AF38469 Chemical Properties,Usage,Production

Uses

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

in vivo

AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat^[1].

References

[1] Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. DOI:10.1016/j.bmcl.2013.11.046

AF38469 Preparation Products And Raw materials

Raw materials

Preparation Products

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1531634-31-7, AF38469Related Search:

AF38469

AF38469 (AF-38469)

CS-2561

Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-

2-((6-Methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid

inhibit,AF 38469,Neurotensin Receptor,Inhibitor,AF38469

2-[(6-Methyl-2-pyridyl)carbamoyl]-5-(trifluoromethyl)benzoic Acid

AF38469, 10 mM in DMSO

AF38469 ，S7478

1531634-31-7