1-(2-Amino-6-fluorophenyl)ethanone
- Product Name
- 1-(2-Amino-6-fluorophenyl)ethanone
- CAS No.
- 869937-08-6
- Chemical Name
- 1-(2-Amino-6-fluorophenyl)ethanone
- Synonyms
- 2’-Amino-6’-fluoroacetophenone;1-(2-Amino-6-fluorophenyl)ethanone;Ethanone, 1-(2-amino-6-fluorophenyl)-
- CBNumber
- CB82747242
- Molecular Formula
- C8H8FNO
- Formula Weight
- 153.15
- MOL File
- 869937-08-6.mol
1-(2-Amino-6-fluorophenyl)ethanone Property
- Boiling point:
- 255.2±20.0 °C(Predicted)
- Density
- 1.201±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.29±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A898688
- Product name
- 1-(2-Amino-6-fluorophenyl)ethanone
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BB20-4041
- Product name
- 1-(2-Amino-6-fluoro-phenyl)-ethanone
- Purity
- ＞97%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 869937086
- Product name
- 1-(2-Amino-6-fluorophenyl)ethanone
- Packaging
- 1g
- Price
- $279.3
- Updated
- 2021/12/16
- Product number
- CD12021942
- Product name
- 1-(2-Amino-6-fluorophenyl)ethanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $282
- Updated
- 2021/12/16
- Product number
- 61-10757
- Product name
- 1-(2-Amino-6-fluorophenyl)ethanone
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
1-(2-Amino-6-fluorophenyl)ethanone Chemical Properties,Usage,Production
Synthesis
75-16-1
77326-36-4
869937-08-6
1. Methylmagnesium bromide (85.76 mL, 3.0 M ethyl ether solution) was added slowly and dropwise to a 20 mL THF solution of 2-amino-6-fluorobenzonitrile (5.0 g, 37 mmol) at -10°C. After the dropwise addition was completed, the reaction mixture was warmed to 70°C and stirred for 5 hours. Upon completion of the reaction, the reaction was quenched with 30 mL of 10% HCl solution and heated to reflux for 1 hour. Subsequently, the pH was adjusted to basic with NaHCO3 and extracted with EtOAc (30 mL x 3). The organic layers were combined, concentrated in vacuum and purified by silica gel column chromatography (eluent: PE/EtOAc = 100:1) to afford 1-(2-amino-6-fluorophenyl)ethanone (2.09 g, yield: 36.8%). 2. 1-(2-Amino-6-fluorophenyl)ethanone (2.0 g, 13.3 mmol) was dissolved in 35 mL of THF, DMAP (1.596 g, 16.6 mmol) and trichloroacetyl chloride (2.42 g, 13.3 mmol) were added, and the mixture was stirred at 0 °C. Subsequently, the reaction mixture was warmed to room temperature and stirred for 7 hours. After completion of the reaction, it was diluted with 50 mL of ice water and extracted with EtOAc (15 mL x 3). The organic layers were combined, concentrated in vacuum and purified by silica gel column chromatography (eluent: PE/EtOAc = 60:1) to afford Intermediate 4b (3.0 g, yield: 75.76%). Mass spectral data: m/z = 297 [M + H]+. 3. Intermediate 4b (1.4 g, 4.7 mmol) was dissolved in 10 mL of DMSO, ammonium acetate (1.3 g, 23 mmol) was added, and stirred at room temperature for 24 hours. After the reaction was completed, it was diluted with cold water, the precipitate was collected by filtration and dried under vacuum to give 5-fluoro-4-methyl-1H-quinazolin-2-one (0.8 g, yield: 95.6%). The product could be used in the next reaction without further purification. Mass spectral data: m/z = 179 [M + H]+. 4. 5-Fluoro-4-methyl-1H-quinazolin-2-one (300 mg, 1.68 mmol) was mixed with 3 mL of POCl3 and stirred at 80°C for 12 hours. After completion of the reaction, the mixture was poured into 20 mL of aqueous K2CO3 and extracted with EtOAc (5 mL x 3). The organic layers were combined, concentrated in vacuum and purified by silica gel column chromatography (eluent: PE/EtOAc = 50:1) to afford 2-chloro-5-fluoro-4-methyl-quinazoline (140 mg, yield: 42.5%) as a white solid. Mass spectral data: m/z = 197 [M + H]+.
References
[1] Patent: WO2013/50527, 2013, A1. Location in patent: Page/Page column 46; 47
1-(2-Amino-6-fluorophenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-Amino-6-fluorophenyl)ethanone Suppliers
- Tel
- 021-58111238 18930958102
- Fax
- 021-58111238
- sales@taifupharm.com
- Country
- China
- ProdList
- 509
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4941
- Advantage
- 55
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-021-54321516 17717324060
- 2719672468@qq.com
- Country
- China
- ProdList
- 2032
- Advantage
- 58
- Tel
- 0510-86838766 13636419861
- 2258830676@qq.com
- Country
- China
- ProdList
- 5044
- Advantage
- 58
- Tel
- 15195022192
- 279776773@qq.com
- Country
- China
- ProdList
- 1996
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 021-34045219 13062664914
- huji@zunlijia.com
- Country
- China
- ProdList
- 10027
- Advantage
- 58
- Tel
- 029-81310890 18165209495
- 2929288192@qq.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 13616542515
- 3845715621@qq.com
- Country
- China
- ProdList
- 158
- Advantage
- 58
- Tel
- 17715136450
- 2439673774@qq.com
- Country
- China
- ProdList
- 15647
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- +8615303909093
- sales@compound-net.com
- Country
- China
- ProdList
- 2914
- Advantage
- 58
- Tel
- +86-0571-85585865 +8613336024896
- CB@aromsyn.com
- Country
- China
- ProdList
- 19183
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58