(R)-4-Propyldihydrofuran-2(3H)-one

ChemicalBook > CAS DataBase List > (R)-4-Propyldihydrofuran-2(3H)-one

(R)-4-Propyldihydrofuran-2(3H)-one

Product Name: (R)-4-Propyldihydrofuran-2(3H)-one
CAS No.: 63095-51-2
Chemical Name: (R)-4-Propyldihydrofuran-2(3H)-one
Synonyms: (R)-4-propyl-dihydro-furan-2-one;(4R)-4-Propyldihydrofuran-2(3H)-one;(4R)-4-propyloxolan-2-one;(4R)-4-propyltetrahydrofuran-2-one;(R)-Dihydro-4-propyl-2(3H)-furanone;(R)-Dihydro-4-propylfuran-2(3H)-one;BR150;Brisetan;Boisacetan;Buvacitan impurity 11
CBNumber: CB82747297
Molecular Formula: C7H12O2
Formula Weight: 128.17
MOL File: 63095-51-2.mol

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(R)-4-Propyldihydrofuran-2(3H)-one Property

Boiling point:: 226.3±8.0 °C(Predicted)
Density: 0.983±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Oil
color: Colourless

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: D495305
Product name: (R)-Dihydro-4-propyl-2(3H)-furanone
Packaging: 1g
Price: $315
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002377
Product name: (R)-4-PROPYLDIHYDROFURAN-2(3H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $504.94
Updated: 2021/12/16

AK Scientific

Product number: 2796CS
Product name: (R)-4-Propyldihydrofuran-2(3H)-one
Packaging: 1g
Price: $223
Updated: 2021/12/16

Ambeed

Product number: A230886
Product name: (R)-4-Propyldihydrofuran-2(3H)-one
Purity: 97%
Packaging: 25g
Price: $1105
Updated: 2021/12/16

Chemenu

Product number: CM244546
Product name: (R)-4-Propyldihydrofuran-2(3H)-one
Purity: 99%
Packaging: 1000g
Price: $3128
Updated: 2021/12/16

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(R)-4-Propyldihydrofuran-2(3H)-one Chemical Properties,Usage,Production

Description

(R)-4-Propyldihydrofuran-2(3H)-one is the key intermediate in the diastereoselective synthesis of Brivaracetam, an active ingredient with antiepileptic properties belonging to the racetam family.

Chemical Properties

(R)-4-Propyldihydrofuran-2(3H)-one is a yellow oily liquid, slightly soluble in chloroform, methanol and ethanol. It needs to be stored at 2-8°C.

Uses

(R)-Dihydro-4-propyl-2(3H)-furanone, is building block used in various chemical synthesis.

Synthesis

Add a solution of H5IO6 (24.429 g, 107.17 mmol) in water (43 mL) to a solution of (R)-2-benzylpentyl acetate (1.180 g) in CCl4 (27 mL) and CH3CN (27 mL) at 0 °C. Add RuCl3·nH2O (0.222 g, 1.07 mmol) slowly to the mixture at 0 °C. Stir the resultant mixture vigorously for 20 hours at room temperature. Quench the reaction with Et2O (50 mL) at 0 °C. Stir the mixture for 30 minutes. Extract the mixture with Et2O (3 × 50 mL).
Wash the combined organic layers with brine (30 mL). Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Dissolve the oil in aqueous NaOH (1 mol L-1, 40 mL). Stir the resulting solution overnight at room temperature. Wash the solution with Et2O (30 mL). Acidify the solution with aqueous HCl (6 mol L-1, 15 mL) at 0 °C. Stir the mixture overnight at room temperature. Saturate the aqueous layer with NaCl. Extract the mixture with Et2O (5 × 40 mL). Wash the combined organic layers with water, saturated aqueous Na2S2O3 (30 mL) and brine (30 mL).
Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Purify the residue by column chromatography on silica gel (hexane/acetone = 3/1) and distillation (162-209 °C/36 mmHg).

(R)-4-Propyldihydrofuran-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-4-Propyldihydrofuran-2(3H)-one manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Brivaracetam Impurity 19 63095-51-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-27

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: (R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2
Price: US $0.00/KH
Min. Order: 5KH
Purity: 99
Supply Ability: 10Tons
Release date: 2024-06-14

Hebei Xinsheng New Material Technology Co., LTD.

Product: (R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 Ton
Release date: 2023-11-16

63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-oneRelated Search:

(R)-Ethyl 3-(bromomethyl)hexanoate Brivaracetam Impurity 10 Brivaracetam Impurity 14 (Z)-2-propylhept-2-enal INTERMEDIATES tert-Butyl (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid Brivaracetam Impurity 21 Brivaracetam-d7 Dihydro-4-propyl-2(3H)-furanone Brivaracetam (alfaR, 4R)-Isomer tert-butyl (R)-3-(hydroxymethyl)hexanoate (4S)-BrivaracetaM Brivaracetam (alfaR, 4S)-Isomer Brivaracetam (Racemate) (R)-4-Propyldihydrofuran-2(3H)-one Brivaracetam brivaracetam intermediate 3

brivaracetam intermediate 1

Brivaracetam Intermediate

(R)-Dihydro-4-propyl-2(3H)-furanone

(R)-4-propyl-dihydro-furan-2-one

(R)-4-propyldihydrofuran-2(3H)-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

(4R)-4-Propyldihydrofuran-2(3H)-one

2(3H)-Furanone,dihydro-4-propyl-,(R)-

Boisacetan

Brivaracetam Impurity 13

(+)-(R)-4-propyl-4,5-dihydroturan-2(3H)-one

2(3H)-Furanone, dihydro-4-propyl-, (R)- (9CI)

(R)-4-propyl-4,5-dihydrofuran-2(3H)-one(BR50)

Brivaracetam Impurity 40

(+)-(R)-4-propyl-4,5- dihydrofuran-2(3H)-one

(R)-4-Propyldihydrofuran-2(3H)-one(For export only)

(R)-Dihydro-4-propylfuran-2(3H)-one

(4R)-4-propyloxolan-2-one

(4R)-4-propyltetrahydrofuran-2-one

Brisetan

(R)-4-Propyldihydrofuran-2(3H)-One/ Intermediate Of Brivaracetam

BR150

(R)-4-Propyldihydrofuran-2(3H)-one(Briveracetam KSM)

(R)-4-propyI-dihydro-furan-2-one

(R)-4-propylidihydrofuran-2(3H)-4-one

Buvacitan impurity 11

63095-51-2