IWP 4

Product Name: IWP 4
CAS No.: 686772-17-8
Chemical Name: IWP 4
Synonyms: IWP 4;CS-2394;IWP4;IWP 4;IWP-4 >=95% (HPLC);Wnt Inhibitor IWP-4;Inhibitor of Wnt Production-4;IWP-4,inhibit,IWP 4,Inhibitor,Wnt,IWP4;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
CBNumber: CB82748092
Molecular Formula: C23H20N4O3S3
Formula Weight: 496.62
MOL File: 686772-17-8.mol

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IWP 4 Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: insoluble in H2O; insoluble in EtOH; insoluble in DMSO
pka: 9.01±0.70(Predicted)
form: powder
color: white to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1114
Product name: IWP-4
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $216
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1114
Product name: IWP-4
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $823
Updated: 2024/03/01

Cayman Chemical

Product number: 13954
Product name: IWP-4
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 13954
Product name: IWP-4
Purity: ≥95%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 13954
Product name: IWP-4
Purity: ≥95%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

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IWP 4 Chemical Properties,Usage,Production

Uses

IWP 4 is a Porcn inhibitor.

Biological Activity

iwp 4 is an inhibitor of wnt production. iwp 4 impairs wnt pathway activity (ic50 = 25 nm) by inactivating porcupine, a membrane-bound acyltransferase responsible for attaching a palmitoyl group to wnt proteins, which is essential to wnt signaling and wnt secretion. the wnt family of signaling proteins is involved in most aspects of embryonic development and postembryonic tissue homeostasis. hyperactivation of the wnt/β-catenin pathway induces premature senescence of stem cells and age-related loss of stem cell function. in cancer, hyperactivation of the wnt/β-catenin pathway often exists along with mutations in other cell growth regulatory genes, which results in aberrant cell growth. thus, iwp 4 could serve a useful tool for researching tissue regeneration and wnt ligand-dependent tumors. iwp 4 has been used for inducing cardiomyocyte differentiation from human pluripotent stem cells.1. chen b, dodge me, tang w, et al. small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. nature chemical biology, 2009, 5(2): 100-107.2. lian x, hsiao c, wilson g, et al. robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical wnt signaling. proceedings of the national academy of sciences of the united states of america, 2012, 109(27): e1848-1857.

Biochem/physiol Actions

IWP-4 blocks Wnt family member 5a. It blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways.

storage

Store at +4°C

IWP 4 Preparation Products And Raw materials

Raw materials

Preparation Products

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IWP 4 Suppliers

China 42 United Kingdom 2 United States 11 Global 55

BOC Sciences

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Sigma-Aldrich

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Shanghai Changyan Chem & Tech Co., Ltd.

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Yujinpharma(Tianjin) Technology Co.,Ltd.

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686772-17-8, IWP 4Related Search:

IWP 4

Wnt Inhibitor IWP-4

2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

IWP4;IWP 4

CS-2394

Inhibitor of Wnt Production-4

Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-

IWP-4 >=95% (HPLC)

IWP-4,inhibit,IWP 4,Inhibitor,Wnt,IWP4

686772-17-8

C23H20N4O3S3