TH287

ChemicalBook > CAS DataBase List > TH287

Product Name: TH287
CAS No.: 1609960-30-6
Chemical Name: TH287
Synonyms: TH287;CS-1671;Centicin;Septigen;TH287, >98%;TH287;TH-287;Oksitselanim;TH287 hydrochloride;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
CBNumber: CB82749064
Molecular Formula: C11H10Cl2N4
Formula Weight: 269.13
MOL File: 1609960-30-6.mol

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TH287 Property

Boiling point:: 512.2±60.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 5.91±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1069
Product name: TH287 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1069
Product name: TH287 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $527
Updated: 2022/05/15

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 10mg
Price: $151
Updated: 2024/03/01

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TH287 Chemical Properties,Usage,Production

Description

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC₅₀ = 0.8 nM) that selectively kills cancer cell lines (IC₅₀s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC₅₀s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

Uses

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

References

1. gad h, koolmeister t, jemth as et al. mth1 inhibition eradicates cancer by preventing sanitation of the dntp pool. nature. 2014 apr 10;508(7495):215-21.

TH287 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TH287 manufacturers

Career Henan Chemical Co

Product: TH287 1609960-30-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1609960-30-6, TH287Related Search:

N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester TH588

TH287 hydrochloride

TH287

6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine

TH287;TH-287

CS-1671

TH287, >98%

2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-

6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

Centicin

Oksitselanim

Septigen

1609960-30-6

Inhibitors