ICA-105574
- Product Name
- ICA-105574
- CAS No.
- 316146-57-3
- Chemical Name
- ICA-105574
- Synonyms
- ICA-105574;3-nitro-N-(4-phenoxyphenyl)-benzamide;Benzamide, 3-nitro-N-(4-phenoxyphenyl)-;activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel
- CBNumber
- CB82750387
- Molecular Formula
- C19H14N2O4
- Formula Weight
- 334.33
- MOL File
- 316146-57-3.mol
ICA-105574 Property
- Boiling point:
- 430.9±30.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >20mg/mL
- pka
- 11.76±0.70(Predicted)
- color
- off-white to light tan
- InChI
- InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
- InChIKey
- GDWKBKTVROCPNZ-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36-43-50/53
- Safety Statements
- 26-36/37-60-61
- RIDADR
- UN 3077 9 / PGIII
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CBL0000327
- Product name
- ICA-105574
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $684.81
- Updated
- 2021/12/16
- Product number
- CBL0000327
- Product name
- ICA-105574
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $977.48
- Updated
- 2021/12/16
- Product number
- DC22960
- Product name
- ICA-105574
- Purity
- >98%
- Packaging
- 1g
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- DC22960
- Product name
- ICA-105574
- Purity
- >98%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
ICA-105574 Chemical Properties,Usage,Production
Description
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].
References
[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.
ICA-105574 Preparation Products And Raw materials
Raw materials
Preparation Products
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