ICA-105574

Product Name: ICA-105574
CAS No.: 316146-57-3
Chemical Name: ICA-105574
Synonyms: ICA-105574;3-nitro-N-(4-phenoxyphenyl)-benzamide;Benzamide, 3-nitro-N-(4-phenoxyphenyl)-;activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel
CBNumber: CB82750387
Molecular Formula: C19H14N2O4
Formula Weight: 334.33
MOL File: 316146-57-3.mol

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ICA-105574 Property

Boiling point:: 430.9±30.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >20mg/mL
pka: 11.76±0.70(Predicted)
form: Solid
color: off-white to light tan
InChI: InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
InChIKey: GDWKBKTVROCPNZ-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1

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Safety

Hazard Codes: Xi,N
Risk Statements: 36-43-50/53
Safety Statements: 26-36/37-60-61
RIDADR: UN 3077 9 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CBL0000327
Product name: ICA-105574
Purity: 95.00%
Packaging: 5MG
Price: $684.81
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CBL0000327
Product name: ICA-105574
Purity: 95.00%
Packaging: 25MG
Price: $977.48
Updated: 2021/12/16

DC Chemicals

Product number: DC22960
Product name: ICA-105574
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

DC Chemicals

Product number: DC22960
Product name: ICA-105574
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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ICA-105574 Chemical Properties,Usage,Production

Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].

References

[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.

ICA-105574 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICA-105574 Suppliers

Canada 1 China 33 China Hong Kong 1 Russia 1 Ukraine 1 United States 4 Global 41

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316146-57-3, ICA-105574Related Search:

3-nitro-N-(4-phenoxyphenyl)-benzamide

ICA-105574

Benzamide, 3-nitro-N-(4-phenoxyphenyl)-

activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel

316146-57-3