ChemicalBook > CAS DataBase List > 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

Product Name
1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
CAS No.
1255516-86-9
Chemical Name
1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
Synonyms
MS-1020;MS-1020 >=98% (HPLC);1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide;1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide;1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide;2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-
CBNumber
CB82750655
Molecular Formula
C21H18N2O3
Formula Weight
346.38
MOL File
1255516-86-9.mol
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1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide Property

storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL at 60°C
form 
powder
color 
white to tan
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0204
Product name
MS-1020
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0204
Product name
MS-1020
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2022/05/15
Cayman Chemical
Product number
14273
Product name
MS-1020
Purity
≥95%
Packaging
1mg
Price
$93
Updated
2024/03/01
Usbiological
Product number
045047
Product name
MS-1020
Packaging
1mg
Price
$303
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CR1-3501-M001
Product name
MS-1020
Purity
≥95%(NMR)
Packaging
1mg
Price
$65
Updated
2021/12/16
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1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide Chemical Properties,Usage,Production

Description

MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM. It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death.

1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

1255516-86-9, 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamideRelated Search:


  • 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide
  • 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
  • MS-1020
  • 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide
  • 2-Naphthalenecarboxamide, 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-
  • MS-1020 >=98% (HPLC)
  • 1255516-86-9