2-[(1-Bromo-2-naphthalenyl)oxy]-N-3-pyridinyl-acetamide

2-[(1-Bromo-2-naphthalenyl)oxy]-N-3-pyridinyl-acetamide Property

Boiling point:

584.8±35.0 °C(Predicted)

Density 

1.523±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble20mg/mL, clear

form 

powder

pka

12.02±0.70(Predicted)

color 

white to beige

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-[(1-Bromo-2-naphthalenyl)oxy]-N-3-pyridinyl-acetamide Chemical Properties,Usage,Production

Uses

VU0405601 is a novel selective hERG blocker.

Biological Activity

VU0405601 is a hERG (the human Ether-à-go-go-Related Gene) agonist th at increased the IC50 of dofetilide from 38.7 nM to 76.3 nM. VU0405601 protects against arrhythmias induced by hERG inhibition.