ChemicalBook > CAS DataBase List > N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

Product Name
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
CAS No.
883976-12-3
Chemical Name
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Synonyms
M8-B;M8 B HCl;M8-B hydrochloride;M8-B hydrochloride >=98% (HPLC);M8-B Hydrochloride, 10 mM in DMSO;M8 B Hydrochloride,M-8-B Hydrochloride,M8B Hydrochloride;N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride;N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride;2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride
CBNumber
CB82750701
Molecular Formula
C22H25ClN2O3S
Formula Weight
432.9635
MOL File
883976-12-3.mol
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N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: soluble2mg/mL, clear (warmed)
form 
powder
color 
white to beige
Water Solubility 
H2O: 2mg/mL, clear (warmed)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0893
Product name
M8-B hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0893
Product name
M8-B hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$491
Updated
2025/07/31
Cayman Chemical
Product number
21646
Product name
M8-B (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21646
Product name
M8-B (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
21646
Product name
M8-B (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
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N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Chemical Properties,Usage,Production

Description

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.

Uses

M8 B Hydrochloride is a channel blocker of cold receptor TRPM8.

in vivo

M8-B (6 mg/kg; i.v. or i.p.) decreases deep body body temperature (Tb) in rats and mouse[1].

Animal Model:Trpm8+/+ rats and mice[1]
Dosage:6 mg/kg
Administration:I.v. or i.p.
Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.

IC 50

TRPM8

storage

Store at +4°C

References

[1] M CAMILA ALMEIDA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.[J]. Journal of Neuroscience, 2012, 32 6: 2086-2099. DOI: 10.1523/jneurosci.5606-11.2012

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Suppliers

China 51 United Kingdom 2 United States 7 Global 60
TargetMol Chemicals Inc.
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Cayman Chemical Company
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883976-12-3, N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochlorideRelated Search:


  • M8-B hydrochloride
  • N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride
  • N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
  • 2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride
  • M8-B
  • M8-B hydrochloride >=98% (HPLC)
  • M8 B Hydrochloride,M-8-B Hydrochloride,M8B Hydrochloride
  • M8 B HCl
  • M8-B Hydrochloride, 10 mM in DMSO
  • 883976-12-3