3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

ChemicalBook > CAS DataBase List > 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

Product Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
CAS No.: 1290541-46-6
Chemical Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
Synonyms: BO2;B02;CS-2461;RAD51 Inhibitor B02;RAD51 Inhibitor B02 >=98% (HPLC);RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem;(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one;3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-;Apoptosis,RAD-51 Inhibitor B02,B-02,B 02,RAD51,RAD51 Inhibitor B02,Inhibitor,inhibit
CBNumber: CB82751056
Molecular Formula: C22H17N3O
Formula Weight: 339.39
MOL File: 1290541-46-6.mol

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3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Property

Melting point:: 174-175o C
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
form: powder
color: faint yellow to dark yellow
Stability:: Hygroscopic

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0364
Product name: RAD51 Inhibitor B02
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: 553525
Product name: RAD51 Inhibitor, B02
Packaging: 25mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 22133
Product name: RAD51 Inhibitor B02
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22133
Product name: RAD51 Inhibitor B02
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0364
Product name: RAD51 Inhibitor B02
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $378.6
Updated: 2024/03/01

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3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Chemical Properties,Usage,Production

Uses

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone is an inhibitor of human RAD51. RAD51 is involved in DNA repair and small molecules that inhibits RAD51 may be used to improve the efficacy of chemotherapy.

Uses

RAD51 Inhibitor B02 has been used:

to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
for RAD51 inhibition in porcine embryos
as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Definition

ChEBI: 3-(phenylmethyl)-2-[2-(3-pyridinyl)ethenyl]-4-quinazolinone is a member of quinazolines.

General Description

A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC₅₀ = 27.4 μM). Does not affect RecA even at much higher concentration (~250 μM). Directly interacts with RAD51 (K_d = 5.6 μM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

storage

Store at +4°C

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1290541-46-6, 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinoneRelated Search:

RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

CS-2461

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

RAD51 Inhibitor B02

B02

BO2

(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one

4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-

RAD51 Inhibitor B02 >=98% (HPLC)

Apoptosis,RAD-51 Inhibitor B02,B-02,B 02,RAD51,RAD51 Inhibitor B02,Inhibitor,inhibit

1290541-46-6