CYM50179

Product Name: CYM50179
CAS No.: 1355026-47-9
Chemical Name: CYM50179
Synonyms: ML-178;CYM50179;CYM 50179;CYM 50179 >=98% (HPLC);2,6-Dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-pyridine;Pyridine, 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-;LPL Receptor,CYM 50179,Inhibitor,ML 178,autoimmune diseases,ML178,hrombocytopenia,CYM-50179,Lysophospholipid Receptor,viral infections,inhibit
CBNumber: CB82751076
Molecular Formula: C13H9Br2Cl2NO2
Formula Weight: 441.93006
MOL File: 1355026-47-9.mol

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CYM50179 Property

storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18527
Product name: ML-178
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18527
Product name: ML-178
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18527
Product name: ML-178
Purity: ≥95%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 18527
Product name: ML-178
Purity: ≥95%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

TRC

Product number: M425180
Product name: ML-178
Packaging: 250mg
Price: $1420
Updated: 2021/12/16

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CYM50179 Chemical Properties,Usage,Production

Uses

ML-178 activates the S1P4 receptor, but is inactive against S1P1, S1P2, S1P3, and S1P5.

Definition

ChEBI: 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine is a dichlorobenzene.

Biological Activity

ml-178 is a novel and selective s1p4 activator with ec50 value of 46.3 nm [1].sphingosine-1-phosphate (s1p) is an extracellular lipid mediator released by activated blood platelets that serves to influence heart rate, coronary artery caliber, endothelial integrity, lung epithelial integrity and lymphocyte recirculation through five of the s1p receptors (s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8). s1p4 receptor is coupled to gαi and gαo g proteins and activates erk, mapk and plc downstream pathways [1].ml-178 is a novel and selective s1p4 activator. ml178 activated s1p4 receptor with an ec50 of 46.3 nm, and is inactive against other members of the receptor family, with ec50s > 50 μm against s1p1, s1p2, s1p3, and s1p5 receptors. ml178 was inhibited by an s1p4 receptor-selective antagonist with an ic50 of 0.83 μm. ml178 was nontoxic to u2os cells with a cc50 of > 20 μm. ml178 was generally inactive against a broad array of off targets, including receptors, transporters, or ion channels [1].

References

[1]. guerrero m, urbano m, velaparthi s, et al. probe development efforts to identify novel agonists of the sphingosine 1-phosphate receptor 4 (s1p4). probe reports from the nih molecular libraries program [internet]. bethesda (md): national center for biotechnology information (us); 2010-.2010 oct 12 [updated 2011 dec 12].

CYM50179 Preparation Products And Raw materials

Raw materials

Preparation Products

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CYM50179 Suppliers

China 13 United States 6 Global 19

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44806
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3023
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2613
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

1355026-47-9, CYM50179Related Search:

CYM50308 1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358) N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride

2,6-Dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-pyridine

CYM 50179

CYM50179

ML-178

Pyridine, 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-

CYM 50179 >=98% (HPLC)

LPL Receptor,CYM 50179,Inhibitor,ML 178,autoimmune diseases,ML178,hrombocytopenia,CYM-50179,Lysophospholipid Receptor,viral infections,inhibit

1355026-47-9

C13H9Br2Cl2NO2