TP2 Property

Boiling point:

463.5±45.0 °C(Predicted)

Density 

1.490±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

pka

10.33±0.20(Predicted)

color 

white to beige

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

TP2 Chemical Properties,Usage,Production

Definition

ChEBI: Thiophene-2 is an organosulfur heterocyclic compound.

Biological Activity

Thiophene-2 (TP2) is an inhibitor of polyketide synthase 13 (Pks13), which plays a critical role in the biosynthesis of mycolic acid, an essential component of the cell wall in M. tuberculosis, and is a potential new target for tuberculosis treatment. TP2 inhibits FadD32-dependent loading of the mycolic acid precursor meromycoloyl chain onto acyl carrier protein (ACP) domains located at the N terminus of Pks13, preventing synthesis of mycolic acid and resulting in mycobacterial cell death. TP2 bacteriosidal activity is equivalent to treatment with the first-line drug isoniazid, and enhances its activity, but is less likely to cause resistance. The minimal inhibitory concentration (MIC) values of TP2 against drug-susceptible multidrug-resistant M. tuberculosis strains is approximately 1 μM.