STROPHANTHIDIN Property

Melting point:

169°C

alpha 

D25 +43.1° (c = 2.8 in methanol)

Boiling point:

446.1°C (rough estimate)

Density 

1.432±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.4593 (estimate)

storage temp. 

-20°C

solubility 

ethanol: complete50mg/mL, clear, colorless to yellow

pka

13.92±0.70(Predicted)

form 

Solid

color 

White to off-white

optical activity

+43.125 (c 2.8, methanol)

Safety

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

FH5425000

Toxicity

LD100 i.v. in cats: 0.337 mg/kg (Graebner, Geisel)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

STROPHANTHIDIN Chemical Properties,Usage,Production

Uses

cardiotonic

Uses

Strophanthidin was used to synthesize acetylstrophanthidin and the effect on neurotransmitter release from dog saphenous vein was studied.³

Definition

ChEBI: Strophanthidin is a 3beta-hydroxy steroid, a 14beta-hydroxy steroid, a 5beta-hydroxy steroid, a 19-oxo steroid, a member of cardenolides and a steroid aldehyde. It is functionally related to a 5beta-cardanolide.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Strophanthidin is a cardiotonic steroid that elevates the activity of Na+/K+-ATPase in cardiac myocytes.1 It decreases the potassium content and raises the sodium content in rabbit renal cortex slices.2