4-AMINO-6-BROMO (1H)INDAZOLE
- Product Name
- 4-AMINO-6-BROMO (1H)INDAZOLE
- CAS No.
- 885518-50-3
- Chemical Name
- 4-AMINO-6-BROMO (1H)INDAZOLE
- Synonyms
- 4-AMINO-6-BROMOINDAZOLE;Indazol-4-amine, 6-bromo-;6-broMo-1H-indazol-4-aMine;6-Bromo-1H-indazole-4-amino;1H-Indazol-4-aMine, 6-broMo-;4-AMINO-6-BROMO (1H)INDAZOLE;6-Bromo-1H-indazol-4-ylamine;4-AMINO-6-BROMO (1H)INDAZOLE ISO 9001：2015 REACH
- CBNumber
- CB8286707
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- Mol file
4-AMINO-6-BROMO (1H)INDAZOLE Property
- Boiling point:
- 426.5±25.0 °C(Predicted)
- Density
- 1.867±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.39±0.40(Predicted)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B683735
- Product name
- 6-Bromo-1H-indazol-4-amine
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- FA59685
- Product name
- 4-Amino-6-bromo-1H-indazole
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- Z5266
- Product name
- 6-Bromo-1H-indazol-4-amine
- Packaging
- 5g
- Price
- $392
- Updated
- 2021/12/16
- Product number
- FA59685
- Product name
- 4-Amino-6-bromo-1H-indazole
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FA59685
- Product name
- 4-Amino-6-bromo-1H-indazole
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
4-AMINO-6-BROMO (1H)INDAZOLE Chemical Properties,Usage,Production
Uses
6-Bromo-1H-indazol-4-amine is used as a reagent in the synthesis of indazole derivatives as PI3 kinase inhibitors useful in the treatment of PI3 kinase-mediated diseases.
Synthesis
885518-46-7
885518-50-3
General procedure for the synthesis of 4-amino-6-bromo-1H-indazole from 4-nitro-6-bromo-1H-indazole: 4-nitro-1H-indazole (commercially available, CAS: 2942-40-7, 1.4 g, 8.26 mmol) or 6-bromo-4-nitro-1H-indazole (commercially available, CAS: 885518-46-7, 2.0 g, 8.26 mmol) in a round-bottomed flask containing ethanol (20 mL) and water (10 mL) as the solvent mixture. Ammonium chloride (221.5 mg, 4.13 mmol) was added and stirred for 5 min at room temperature. Subsequently, iron powder (Part I: 1.3 g, 23.46 mmol; Part II: 1.0 g, 17.86 mmol) was added in batches and stirred at 80 °C for 5 min and 20 min, respectively. Immediately after completion of the reaction, the reaction mixture was filtered and the filtrate was washed with ethanol (10 mL). The filtrate was concentrated under reduced pressure and then dissolved in ethyl acetate (8 mL). The organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated again. The resulting solid was purified by silica gel column chromatography using petroleum ether with ethyl acetate (8:1) as eluent to afford the target product 4-amino-6-bromo-1H-indazole (10a: 379.0 mg, 93% yield; or 10b: 1.62 g, 92% yield) as a yellow solid.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 23, p. 6194 - 6205
[2] Patent: CN107805221, 2018, A. Location in patent: Paragraph 0083; 0084; 0085; 0087
[3] Patent: CN108689937, 2018, A. Location in patent: Paragraph 0138; 0149; 0154; 0155; 0156
[4] Patent: WO2017/68064, 2017, A1. Location in patent: Page/Page column 186
4-AMINO-6-BROMO (1H)INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
4-AMINO-6-BROMO (1H)INDAZOLE Suppliers
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3764
- Advantage
- 58
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 3993
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- 027-65318838 13646286950
- sales@devinchem.com
- Country
- China
- ProdList
- 2953
- Advantage
- 58
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2339
- Advantage
- 58
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2647
- Advantage
- 55
View Lastest Price from 4-AMINO-6-BROMO (1H)INDAZOLE manufacturers
- Product
- 4-AMINO-6-BROMO (1H)INDAZOLE 885518-50-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03