ChemicalBook > CAS DataBase List > RO 25-6981 HYDROCHLORIDE

RO 25-6981 HYDROCHLORIDE

Product Name
RO 25-6981 HYDROCHLORIDE
CAS No.
919289-58-0
Chemical Name
RO 25-6981 HYDROCHLORIDE
Synonyms
Ro 256981 HCl;Ro 25-6981 HCl;Ro 25 6981 HCl;Ro 25-6981 hydrochloride hydrate;4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride;[R-(R*,S*)]-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL HYDROCHLORIDE;[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate
CBNumber
CB8289076
Molecular Formula
C22H30ClNO2
Formula Weight
375.93
MOL File
919289-58-0.mol
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RO 25-6981 HYDROCHLORIDE Property

solubility 
H2O: 2 mg/mL
form 
powder
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R7150
Product name
Ro 25-6981 hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
5MG
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
R7150
Product name
Ro 25-6981 hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
25MG
Price
$613
Updated
2024/03/01
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RO 25-6981 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Ro 25-6981 hydrochloride hydrate has been used:

  • as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
  • as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
  • to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus

Biochem/physiol Actions

Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.

RO 25-6981 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 25-6981 HYDROCHLORIDE Suppliers

China 6 Switzerland 1 United States 3 Global 10
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30231
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19699
Advantage
58
Merck KGaA
Tel
(+86) 21 2033 8288
Email
sigmaname@qq.com
Country
CHINA
ProdList
292362
Advantage
58

919289-58-0, RO 25-6981 HYDROCHLORIDERelated Search:

1-Piperidinepropanol

  • [R-(R*,S*)]-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL HYDROCHLORIDE
  • 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
  • [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride
  • [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate
  • Ro 25-6981 hydrochloride hydrate
  • Ro 25 6981 HCl
  • Ro 256981 HCl
  • Ro 25-6981 HCl
  • 919289-58-0
  • C22H29NO2HCl
  • Cell Signaling and Neuroscience
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels
  • BioChemical
  • Cell Biology
  • Glutamate receptor