2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

Product Name: 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
CAS No.: 1638211-04-7
Chemical Name: 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
Synonyms: ML303;ML303, 10 mM in DMSO;ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor;2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol;Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-
CBNumber: CB82919205
Molecular Formula: C21H16F3N3O2
Formula Weight: 399.37
MOL File: 1638211-04-7.mol

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2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Property

Boiling point:: 483.6±45.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 20mg/mL, clear
form: powder
pka: 8.01±0.20(Predicted)
color: white to beige
InChI: 1S/C21H16F3N3O2/c1-12-19-16(13-3-8-17(28)18(11-13)29-2)9-10-25-20(19)27(26-12)15-6-4-14(5-7-15)21(22,23)24/h3-11,28H,1-2H3
InChIKey: YBRHGNCGFMRGSV-UHFFFAOYSA-N
SMILES: CC1=NN(C2=CC=C(C(F)(F)F)C=C2)C3=NC=CC(C4=CC=C(O)C(OC)=C4)=C31

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1145
Product name: ML303
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $336
Updated: 2026/04/30

Sigma-Aldrich

Product number: SML1145
Product name: ML303
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $132
Updated: 2022/05/15

ChemScene

Product number: CS-0090741
Product name: ML303
Purity: >98.0%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: SYN5460
Product name: ML303
Packaging: 100mg
Price: $931
Updated: 2021/12/16

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2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Chemical Properties,Usage,Production

Uses

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

Biological Activity

It belongs to the pyrazolopyridine family.', 'ML303 is a potent inhibitor (IC50 = 155 nM) of the influenza viral protien NS1. NS1 enhances virulence by inhibiting host cell immune responses, including the expression of IFN-b, and regulating synthesis, splicing and translation of viral RNA.

References

[1] Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. DOI:10.1016/j.bmcl.2019.02.027

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Suppliers

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1638211-04-7, 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenolRelated Search:

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

ML303

ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor

Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-

ML303, 10 mM in DMSO

1638211-04-7