ChemicalBook > CAS DataBase List > 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

Product Name
2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
CAS No.
1638211-04-7
Chemical Name
2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
Synonyms
ML303;ML303, 10 mM in DMSO;ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor;2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol;Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-
CBNumber
CB82919205
Molecular Formula
C21H16F3N3O2
Formula Weight
399.37
MOL File
1638211-04-7.mol
More
Less

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Property

Boiling point:
483.6±45.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 20mg/mL, clear
form 
powder
pka
8.01±0.20(Predicted)
color 
white to beige
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1145
Product name
ML303
Purity
≥98% (HPLC)
Packaging
25mg
Price
$313
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1145
Product name
ML303
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2022/05/15
ChemScene
Product number
CS-0090741
Product name
ML303
Purity
>98.0%
Packaging
1mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
SYN5460
Product name
ML303
Packaging
100mg
Price
$931
Updated
2021/12/16
More
Less

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Chemical Properties,Usage,Production

Uses

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

Biological Activity

It belongs to the pyrazolopyridine family.', 'ML303 is a potent inhibitor (IC50 = 155 nM) of the influenza viral protien NS1. NS1 enhances virulence by inhibiting host cell immune responses, including the expression of IFN-b, and regulating synthesis, splicing and translation of viral RNA.

References

[1] Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. DOI:10.1016/j.bmcl.2019.02.027

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Suppliers

China 39 United States 5 Global 44
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

1638211-04-7, 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenolRelated Search:


  • 2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
  • ML303
  • ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor
  • Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-
  • ML303, 10 mM in DMSO
  • 1638211-04-7