ChemicalBook > CAS DataBase List > 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

Product Name
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
CAS No.
34823-86-4
Chemical Name
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
Synonyms
GTP-14564;3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE;1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-;1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
CBNumber
CB8298108
Molecular Formula
C15H10N2O
Formula Weight
234.25
MOL File
34823-86-4.mol
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1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Property

Melting point:
222-223 °C
Boiling point:
459.1±25.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
pka
12.72±0.30(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17543
Product name
GTP 14564
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17543
Product name
GTP 14564
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
17543
Product name
GTP 14564
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Tocris
Product number
2086
Product name
GTP14564
Purity
≥99%(HPLC)
Packaging
10
Price
$122
Updated
2021/12/16
TRC
Product number
G800505
Product name
GTP14564
Packaging
1mg
Price
$40
Updated
2021/12/16
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1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Chemical Properties,Usage,Production

Description

GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.

Uses

GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor.

Definition

ChEBI: 3-phenyl-1H-benzofuro[3,2-c]pyrazole is a member of pyrazoles and a ring assembly.

Biological Activity

Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic.

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Suppliers

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34823-86-4, 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDENRelated Search:

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

  • GTP-14564
  • 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
  • 3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE
  • 1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-
  • 34823-86-4