2-[(benzyloxy)methyl]propane-1,3-diol
- Product Name
- 2-[(benzyloxy)methyl]propane-1,3-diol
- CAS No.
- 117087-18-0
- Chemical Name
- 2-[(benzyloxy)methyl]propane-1,3-diol
- Synonyms
- 2-[(benzyloxy)methyl]propane-1,3-diol;2-[(Benzyloxy)methyl]-1,3-propanediol;2-(phenylmethoxymethyl)propane-1,3-diol;2-[(Phenylmethoxy)methyl]-1,3-propanediol;1,3-Propanediol, 2-[(phenylmethoxy)methyl]-
- CBNumber
- CB83032640
- Molecular Formula
- C11H16O3
- Formula Weight
- 196.24
- MOL File
- 117087-18-0.mol
2-[(benzyloxy)methyl]propane-1,3-diol Property
- Boiling point:
- 365.8±27.0 °C(Predicted)
- Density
- 1.130±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.27±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B130558
- Product name
- 2-((Benzyloxy)methyl)propane-1,3-diol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B130558
- Product name
- 2-((Benzyloxy)methyl)propane-1,3-diol
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 6284CR
- Product name
- 2-((Benzyloxy)methyl)propane-1,3-diol
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 6284CR
- Product name
- 2-((Benzyloxy)methyl)propane-1,3-diol
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 2607-1-22
- Product name
- 2-[(Benzyloxy)methyl]propane-1,3-diol
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
2-[(benzyloxy)methyl]propane-1,3-diol Chemical Properties,Usage,Production
Synthesis
117087-17-9
117087-18-0
5-((Benzyloxy)methyl)-2,2-dimethyl-1,3-dioxane (5.54 g, 23.44 mmol) was used as a starting material, which was dissolved in methanol (20 mL), followed by the slow addition of 3 N hydrochloric acid (3 mL). The reaction mixture was stirred at 25 °C for 30 min. Upon completion of the reaction, the pH was adjusted to 8 with solid sodium bicarbonate, followed by solvent evaporation. The residue was dissolved in ethyl acetate, filtered through a short silica gel pad and washed with ethyl acetate. The filtrate was concentrated in vacuum to afford 2-((benzyloxy)methyl)propane-1,3-diol (4.39 g, 95% yield) as an off-white solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 1.99-2.07 (m, 1H, CH), 2.74 (s, 2H, 2×OH), 3.60 (d, J = 5.7 Hz, 2H, OCH2), 3.78 (d, J = 5.4 Hz, 4H, 2×OCH2), 4.50 (s, 2H, OCH2Ar). 7.25-7.38 (m, 5H, Ar).
References
[1] European Journal of Medicinal Chemistry, 2009, vol. 44, # 1, p. 239 - 250
[2] Patent: US2008/21032, 2008, A1. Location in patent: Page/Page column 81
[3] Patent: WO2018/149419, 2018, A1. Location in patent: Paragraph 001322; 001323
[4] Patent: WO2016/145142, 2016, A1. Location in patent: Page/Page column 352
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 20, p. 2909 - 2914
2-[(benzyloxy)methyl]propane-1,3-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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