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ceralifimod

Product Name
ceralifimod
CAS No.
891859-12-4
Chemical Name
ceralifimod
Synonyms
ONO-4641;ceralifimod;Ceralifimod (ONO-4641);Ceralifimod (Synonyms: ONO-4641);3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
CBNumber
CB83032842
Molecular Formula
C27H33NO4
Formula Weight
435.56
MOL File
891859-12-4.mol
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ceralifimod Property

Boiling point:
595.9±50.0 °C(Predicted)
Density 
1.172±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
form 
A crystalline solid
pka
2.71±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
24159
Product name
Ceralifimod
Purity
≥95%
Packaging
25mg
Price
$305
Updated
2024/03/01
Tocris
Product number
6690
Product name
Ceralifimod
Purity
≥95%(HPLC)
Packaging
10
Price
$123
Updated
2021/12/16
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ceralifimod Chemical Properties,Usage,Production

Description

Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.

storage

Store at -20°C

ceralifimod Preparation Products And Raw materials

Raw materials

Preparation Products

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ceralifimod Suppliers

China 28 United States 5 Global 33
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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9806
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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58
Jinan Yaoyan Pharmaceutical Co., Ltd.
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Fax
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jnyaoyan@163.com
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China
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3069
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58
Shanghai Medicil Biomedical Co., Ltd.
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021-50822001
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marketing@medicilon.com.cn
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China
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1152
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58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
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0571-85361029
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0571-85361029
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synstar518@163.com
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China
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1990
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58
Taizhou Crene Biotechnology Co. Ltd.
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+86-0576-88813233 +86-13396860566
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sales@pharm-intermediates.com
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China
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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meitaochem@126.com
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meitaochem@126.com
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China
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19103
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Beijing xinyanhui pharmaceutical research and development co., LTD
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13969155946
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1461866103@qq.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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Advanced chemblocks inc
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650-6922368
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sales@achemblock.com
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Changzhou Furuisi Biotechnology Co., Ltd
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Shanghai tingchong biology science and technology co., ltd
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Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.
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Hubei Kele Fine Chemical Co., Ltd
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InvivoChem
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Changzhou Bojia Biomedical Technology Co., Ltd.
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czbjpharma@126.com
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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
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+86-027-59232304 15387063101
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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Nantong QuanYi Biotechnology Co., Ltd
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PharmaBlock Sciences (Nanjing), Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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Chengdu Peter-like Biotechnology Co., Ltd.
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Suzhou ARTK Medchem Co., Ltd.
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Wuhan Topule Biopharmaceutical Co., Ltd
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891859-12-4, ceralifimodRelated Search:


  • Ceralifimod (Synonyms: ONO-4641)
  • ceralifimod
  • ONO-4641
  • 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
  • Ceralifimod (ONO-4641)
  • 891859-12-4