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R-Morinidazole

Product Name
R-Morinidazole
CAS No.
898230-59-6
Chemical Name
R-Morinidazole
Synonyms
R-Morinidazole;Morinidazole (R enantiomer);Morpholinonitrazole impurity 2;R-Morinidazole，MorinidazoleRenantiomer;Morinidazole Impurity 11 (R-Morinidazole);(R)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-, (αR)-
CBNumber
CB83041217
Molecular Formula
C11H18N4O4
Formula Weight
270.29
MOL File
898230-59-6.mol
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R-Morinidazole Property

Boiling point:
521.4±50.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (369.97 mM)
pka
14.14±0.20(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5059
Product name
MorinidazoleRenantiomer
Purity
>98.0%
Packaging
5mg
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-5059
Product name
MorinidazoleRenantiomer
Purity
>98.0%
Packaging
10mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-5059
Product name
MorinidazoleRenantiomer
Purity
>98.0%
Packaging
50mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-5059
Product name
MorinidazoleRenantiomer
Purity
>98.0%
Packaging
100mg
Price
$350
Updated
2021/12/16
Crysdot
Product number
CD31000363
Product name
MorinidazoleRenantiomer
Purity
98+%
Packaging
10mg
Price
$347
Updated
2021/12/16
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R-Morinidazole Chemical Properties,Usage,Production

Uses

(R)-Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. (R)-Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria[1].

in vivo

(R)-Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC50s of 20 mg/kg and 25 mg/kg, respectively[2].
(R)-Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice[3].
Pharmacokinetic parameters of (R)-Morinidazole in control and 5/6 nephrectomized (Nx) rats[3]

GroupCmax (μg/mL)Tmax (h)T1/2 (h)AUC0-t (μg·h/mL)AUC0-∞ (μg·h/mL)CL (mL/h/kg)Vss (mL/kg)MRT (h)
Control rats48.20.081.1687.287.35828051.39
5/6 Nx rats53.20.081.3291.291.35528911.62
Intravenous injection; 50 mg/kg (R)-Morinidazole; Blood samples were collected from retro-orbital venous plexus before the dose (0 hours), at 5, 15, and 30 minutes, and at 1, 2, 4, 6, 8, and 12 hours after the dose.
Animal Model:Renal failure model in SD rats (180-220 g)[3]
Dosage: 50 mg/kg
Administration:Intravenous injection; sacrificed rats at 0.25, 0.75, and 1.50 hours after dose administration
Result:Increased plasma exposures slightly compared with control.

References

[1] Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61. DOI:10.1128/AAC.02414-14
[2] Kong F, et al. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug Metab Dispos. 2017 Jun;45(6):593-603. DOI:10.1124/dmd.116.074492
[3] Lu Aifeng, et al. Application of α-(morpholine-1-yl)methyl-2-methyl-nitroimidazole-1-ethanol as anti-trichomonal agent and amebacide: China, CN1981764[P]. 2007-06-20.

R-Morinidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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R-Morinidazole Suppliers

China 36 India 1 United States 5 Global 42
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
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50
Birdo (Shanghai) Medical Technology Co., Ltd.
Tel
021-58099077
Fax
-
Email
sales@birdochem.com
Country
China
ProdList
185
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
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Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@yongstandards.com
Country
China
ProdList
10000
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55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
Country
China
ProdList
7924
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View Lastest Price from R-Morinidazole manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
R-Morinidazole 898230-59-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-07-17

898230-59-6, R-MorinidazoleRelated Search:


  • R-Morinidazole
  • Morinidazole (R enantiomer)
  • 4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-, (αR)-
  • (R)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol
  • R-Morinidazole，MorinidazoleRenantiomer
  • Morinidazole Impurity 11 (R-Morinidazole)
  • Morpholinonitrazole impurity 2
  • 898230-59-6