ChemicalBook > CAS DataBase List > RO8994

RO8994

Product Name
RO8994
CAS No.
1309684-94-3
Chemical Name
RO8994
Synonyms
RO8994;CS-2264;RO-8994;RO 8994;RO8994;RO-8994;RO 8994;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-;E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase
CBNumber
CB83041727
Molecular Formula
C31H31Cl2FN4O4
Formula Weight
613.51
MOL File
1309684-94-3.mol
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RO8994 Property

Boiling point:
753.5±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM)
form 
A crystalline solid
pka
12.00±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25674
Product name
RO8994
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
25674
Product name
RO8994
Packaging
25mg
Price
$1169
Updated
2024/03/01
Cayman Chemical
Product number
25674
Product name
RO8994
Packaging
5mg
Price
$286
Updated
2024/03/01
Cayman Chemical
Product number
25674
Product name
RO8994
Packaging
10mg
Price
$535
Updated
2024/03/01
TRC
Product number
R637390
Product name
RO8994
Packaging
2.5mg
Price
$200
Updated
2021/12/16
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RO8994 Chemical Properties,Usage,Production

Description

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.

Uses

RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.

RO8994 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO8994 Suppliers

China 43 United States 12 Global 55
Changzhou Chenhong Biotechnology Co., Ltd.
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Shanghai Boyle Chemical Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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HangZhou YuHao Chemical Technology Co., Ltd.
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0571-82693216
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info@yuhaochemical.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Twochem Co.Ltd
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Shanghai Chaolan Chemical Technology Center
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Taizhou Crene Biotechnology Co. Ltd.
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Absin Bioscience Inc.
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InvivoChem
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1309684-94-3, RO8994Related Search:


  • RO8994
  • (2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide
  • CS-2264
  • RO8994;RO-8994;RO 8994
  • RO-8994;RO 8994
  • Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-
  • E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase
  • (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-
  • (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-
  • 1309684-94-3
  • C31H31Cl2FN4O4