ChemicalBook > CAS DataBase List > RO8994

RO8994

Product Name: RO8994
CAS No.: 1309684-94-3
Chemical Name: RO8994
Synonyms: RO8994;CS-2264;RO8994 ，S0167;RO-8994;RO 8994;RO8994, 10 mM in DMSO;RO8994;RO-8994;RO 8994;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'S,5'R)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-
CBNumber: CB83041727
Molecular Formula: C31H31Cl2FN4O4
Formula Weight: 613.51
MOL File: 1309684-94-3.mol

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RO8994 Property

Boiling point:: 753.5±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM)
form: A crystalline solid
pka: 12.00±0.70(Predicted)
color: White to off-white
InChIKey: MURAVORBGFDSMA-ISKXDESKSA-N
SMILES: N1C2=C(C=CC(Cl)=C2)[C@@]2([C@@H](C3=CC=CC(Cl)=C3F)[C@H](C(NC3=CC=C(C(N)=O)C=C3OC)=O)N[C@H]2CC(C)(C)C)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25674
Product name: RO8994
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 25674
Product name: RO8994
Packaging: 25mg
Price: $1169
Updated: 2024/03/01

Cayman Chemical

Product number: 25674
Product name: RO8994
Packaging: 5mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 25674
Product name: RO8994
Packaging: 10mg
Price: $535
Updated: 2024/03/01

TRC

Product number: R637390
Product name: RO8994
Packaging: 2.5mg
Price: $200
Updated: 2021/12/16

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RO8994 Chemical Properties,Usage,Production

Description

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC₅₀ = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC₅₀ value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.

Uses

RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.

References

[1] ZHUMING ZHANG . Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy[J]. Bioorganic & Medicinal Chemistry, 2014, 22 15: Pages 4001-4009. DOI: 10.1016/j.bmc.2014.05.072

RO8994 Preparation Products And Raw materials

Raw materials

Preparation Products

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1309684-94-3, RO8994Related Search:

RO8994

(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

CS-2264

RO8994;RO-8994;RO 8994

RO-8994;RO 8994

Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-

E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase

(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-

RO8994, 10 mM in DMSO

(2'S,3R,4'S,5'R)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

RO8994 ，S0167

1309684-94-3

C31H31Cl2FN4O4