ChemicalBook > CAS DataBase List > RPT-835(alofanib)

RPT-835(alofanib)

Product Name: RPT-835(alofanib)
CAS No.: 1612888-66-0
Chemical Name: RPT-835(alofanib)
Synonyms: RPT835;CS-2880;Alofanib;ES 000835;RPT-835; RPT 835;Alofanib (RPT835);RPT-835(alofanib);Alofanib, 10 mM in DMSO;RPT-835;RPT835;RPT 835;ES 000835;3-[[4-methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic acid
CBNumber: CB83043327
Molecular Formula: C19H15N3O6S
Formula Weight: 413.4
MOL File: 1612888-66-0.mol

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RPT-835(alofanib) Property

Boiling point:: 659.6±65.0 °C(Predicted)
Density: 1.488±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:47.7(Max Conc. mg/mL);115.38(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.57(Max Conc. mM)
form: A crystalline solid
pka: 3.59±0.10(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24)
InChIKey: QUQGQIASFYWKAB-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(S(NC2=CC(C3=CC=CN=C3)=C(C)C=C2[N+]([O-])=O)(=O)=O)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0014684
Product name: Alofanib
Purity: 98.81%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0014684
Product name: Alofanib
Purity: 98.81%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0014684
Product name: Alofanib
Purity: 98.81%
Packaging: 25mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0014684
Product name: Alofanib
Purity: 98.81%
Packaging: 50mg
Price: $720
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573162
Product name: Alofanib
Purity: >98%
Packaging: 100mg
Price: $912.9
Updated: 2021/12/16

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RPT-835(alofanib) Chemical Properties,Usage,Production

Uses

Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity[1][2].

in vivo

In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg, gavage, daily, 40 days, N=10) is well tolerated and results in potent antitumour activity^[1].

Treatment with alofanib (10 mg/kg/d, 0, 3 and 6 d, intraperitoneally) ablates experimental FGF-induced angiogenesis in vivo^[1].

Animal Model:	C57Bl/6 × DBA/2 F1 mice of 22–30 g^[1]
Dosage:	10 mg/kg/d
Administration:	Intraperitoneally, 0, 3 and 6 d
Result:	Alofanib inhibits angiogenesis in mouse models^[1].

IC 50

FGFR2

References

[1] Tsimafeyeu I, et al. Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models. Eur J Cancer. 2016 Jul;61:20-8. DOI:10.1016/j.ejca.2016.03.068
[2] Khochenkov DA, et al. Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2. Bull Exp Biol Med. 2015 Nov;160(1):84-7. DOI:10.1007/s10517-015-3104-5

RPT-835(alofanib) Preparation Products And Raw materials

Raw materials

Preparation Products

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1612888-66-0, RPT-835(alofanib)Related Search:

RPT835

RPT-835(alofanib)

3-(N-(4-methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid

Alofanib (RPT835)

Alofanib

CS-2880

ES 000835

RPT-835;RPT835;RPT 835;ES 000835

RPT-835; RPT 835

Benzoic acid, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-

Apoptosis,FGFR,Inhibitor,inhibit,RPT-835,RPT 835,Fibroblast growth factor receptor,Alofanib

3-[N-[4-Methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic Acid

3-[[4-methyl-2-nitro-5-(3-pyridyl)phenyl]sulfamoyl]benzoic acid

Alofanib, 10 mM in DMSO

1612888-66-0