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Boc-D-Asp-OMe

Product Name
Boc-D-Asp-OMe
CAS No.
137130-65-5
Chemical Name
Boc-D-Asp-OMe
Synonyms
Boc-D-Asp-OMe;(Tert-Butoxy)Carbonyl D-Asp-OMe;N-Boc-D-aspartic acid 1-methyl ester;N-Boc-D-asparticacid1-methylester,97%;α-methyl N-(tert-butoxycarbonyl)aspartate;(R)-3-((tert-butoxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid;N-[(1,1-Dimethylethoxy)carbonyl]-D-aspartic acid 1-methyl ester;(3R)-3-{[(tert-butoxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid;D-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl ester
CBNumber
CB83048524
Molecular Formula
C10H17NO6
Formula Weight
247.25
MOL File
137130-65-5.mol
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Boc-D-Asp-OMe Property

Boiling point:
407.1±40.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.09±0.19(Predicted)
form 
Powder
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
D474280
Product name
N-[(1,1-Dimethylethoxy)carbonyl]-D-asparticAcid1-MethylEster
Packaging
25g
Price
$615
Updated
2021/12/16
AK Scientific
Product number
8320CR
Product name
Boc-D-Asp-OMe
Packaging
1g
Price
$72
Updated
2021/12/16
Activate Scientific
Product number
AS112768
Product name
Boc-D-Asp-OMe
Purity
97%
Packaging
100g
Price
$305
Updated
2021/12/16
Activate Scientific
Product number
AS112768
Product name
Boc-D-Asp-OMe
Purity
97%
Packaging
25g
Price
$97
Updated
2021/12/16
Activate Scientific
Product number
AS112768
Product name
Boc-D-Asp-OMe
Purity
97%
Packaging
5G
Price
$32
Updated
2021/12/16
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Boc-D-Asp-OMe Chemical Properties,Usage,Production

Uses

N-Boc-D-aspartic acid 1-methyl ester is widely used in pharmaceuticals and foods.

Synthesis

80963-12-8

98045-03-5

Boc-L-aspartyl (OBn) (OMe) 14 (5.88 g, 17.43 mmol) was used as a raw material and dissolved in methanol (20 mL) in a 50 mL round bottom flask. A 10% palladium-carbon catalyst was added to the reaction system under nitrogen protection. Subsequently, the gas in the reaction vessel was replaced three times with nitrogen and then three times with hydrogen. The reaction mixture was stirred under hydrogen atmosphere and atmospheric pressure for 6 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product (S)-3-((tert-butoxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid (Compound 15) as a colorless gelatinous liquid (4.1 g, 95% yield). The product had a rotativity [α]21D = 34 (c 0.1, CHCl3).1H NMR (CDCl3, 400MHz) δ: 1.43 (s, 9H), 2.83-2.86 (d, 1H, J = 16.92Hz), 3.01-3.05 (d, 1H, J = 16.68Hz), 3.74 (s, 3H), 4.57 (s, 1H), 4.57 (s, 1H). 1H), 5.55-5.57 (d, 1H, J = 8.12Hz), 10.45 (s, 1H).13C NMR (CDCl3, 100MHz) δ: 28.3, 36.6, 49.7, 52.8, 80.5, 155.5, 171.5, 176.0. IR (KBr) νmax: 3366, 2980, 1719, 1506, 1440. 1719, 1506, 1440, 1395, 1368, 1222, 1165, 1060, 1008, 864, 764, 587 cm-1.

References

[1] Organic and Biomolecular Chemistry, 2007, vol. 5, # 9, p. 1459 - 1465
[2] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2274 - 2276
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 1, p. 15 - 20
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 586 - 590
[5] Carbohydrate Research, 2013, vol. 382, p. 36 - 42

Boc-D-Asp-OMe Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-D-Asp-OMe Suppliers

China 65 United States 3 Global 68
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58

137130-65-5, Boc-D-Asp-OMeRelated Search:


  • Boc-D-Asp-OMe
  • D-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl ester
  • N-[(1,1-Dimethylethoxy)carbonyl]-D-aspartic acid 1-methyl ester
  • N-Boc-D-aspartic acid 1-methyl ester
  • (Tert-Butoxy)Carbonyl D-Asp-OMe
  • (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid
  • N-Boc-D-asparticacid1-methylester,97%
  • α-methyl N-(tert-butoxycarbonyl)aspartate
  • (R)-3-((tert-butoxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid
  • 137130-65-5