ChemicalBook > CAS DataBase List > (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

Product Name
(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
CAS No.
1448440-52-5
Chemical Name
(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Synonyms
CS-2845;SP-13786;UAMC-1110;UAMC-01110;SP 13786,SP13786;SP-13786, 10 mM in DMSO;Fmoc-FAPI-4/ SCHEMBL21257089;SP-13786 (UAMC1110, FAP-IN-1);(S)-N-[2-(2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide;(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
CBNumber
CB83052176
Molecular Formula
C17H14F2N4O2
Formula Weight
344.32
MOL File
1448440-52-5.mol
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(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide Property

Melting point:
>70°C (Decomposed)
Boiling point:
676.4±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
12.43±0.46(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
InChI
InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
InChIKey
PUOOCZVRHBHJRS-NSHDSACASA-N
SMILES
N1C2C(=CC=CC=2)C(C(NCC(N2CC(F)(F)C[C@H]2C#N)=O)=O)=CC=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
153693
Product name
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Purity
95%
Packaging
100mg
Price
$2960
Updated
2021/12/16
Matrix Scientific
Product number
153693
Product name
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Purity
95%
Packaging
250mg
Price
$5514
Updated
2021/12/16
Chemenu
Product number
CM328725
Product name
N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Purity
95%+
Packaging
10g
Price
$7728
Updated
2021/12/16
Crysdot
Product number
CD11254374
Product name
SP-13786
Purity
97%
Packaging
5mg
Price
$125
Updated
2021/12/16
Crysdot
Product number
CD11254374
Product name
SP-13786
Purity
97%
Packaging
10mg
Price
$194
Updated
2021/12/16
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(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide Chemical Properties,Usage,Production

Uses

UAMC1110 is a useful research chemical and a fibroblast activation protein inhibitor displaying low nanomolar inhibitory potency and high selectivity against related dipeptidyl peptidases.

in vivo

UAMC-1110 is the most extensive and prolonged inhibitior of FAP in the PK studies. Pharmacokinetic evaluation in mice of UAMC-1110 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo[1].

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide Suppliers

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1448440-52-5, (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamideRelated Search:

5-DIMETHYLAMINO-1-NAPHTHALENESULFONIC ACID HYDRATE Sulfanilamide

  • (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
  • SP-13786
  • (S)-N-[2-(2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide
  • CS-2845
  • (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (UAMC1110)
  • UAMC-1110
  • 4-Quinolinecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-
  • SP-13786 (UAMC1110, FAP-IN-1)
  • UAMC-01110
  • Fmoc-FAPI-4/ SCHEMBL21257089
  • SP 13786,SP13786
  • UAMC1110, (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin- 1-yl)- 2-oxoethyl)quinoline-4-carboxamide
  • SP-13786, 10 mM in DMSO
  • 1448440-52-5