ChemicalBook > CAS DataBase List > Lorediplon

Lorediplon

Product Name
Lorediplon
CAS No.
917393-39-6
Chemical Name
Lorediplon
Synonyms
Lorediplon;Thionorphine Hydrochloride;Acetamide, N-[2-fluoro-5-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methyl-;N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide;GABA Receptor,γ-Aminobutyric acid Receptor,inhibit,Inhibitor,Lorediplon,Gamma-aminobutyric acid Receptor
CBNumber
CB83053906
Molecular Formula
C20H15FN4O2S
Formula Weight
394.42
MOL File
917393-39-6.mol
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Lorediplon Property

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 14 mg/ml
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23868
Product name
Lorediplon
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23868
Product name
Lorediplon
Purity
≥98%
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
23868
Product name
Lorediplon
Purity
≥98%
Packaging
25mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23868
Product name
Lorediplon
Purity
≥98%
Packaging
50mg
Price
$243
Updated
2024/03/01
ChemScene
Product number
CS-5271
Product name
Lorediplon
Purity
99.78%
Packaging
10mg
Price
$50
Updated
2021/12/16
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Lorediplon Chemical Properties,Usage,Production

Description

Lorediplon is a non-benzodiazepine belonging to pyrazolopyrimidine family isunderdevelopment for the management for insomnia. Lorediplon acts by modulationof the GABAgreceptor. Its long plasma half-life has the potential of hypnotic effect. Ithas the potential for maintenance of sleep and the sleep architecture. In the phase Ipharmacodynamic study,it showed better efficacy in quality and maintenance ofsleep as compared with zolpidem. It has been shown to be well tolerated, safe with noresidual effects as compared with other sedative-hypnotic. Currently, the drug has completed Phase ll clinical trial. Results indicated strongefficacy in sleep maintenance with an acceptable safety profile. It also seems topreserve natural sleep architecture.

Uses

Lorediplon is GABAA receptor modulator and is used in the treatment of insomnia.

Biological Activity

Lorediplon is a ligand for α1 subunit-containing GABAA receptors. In vivo, lorediplon inhibits spontaneous motor activity and increases duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow wave sleep (SWS) and paradoxical sleep (PS) in mice. Formulations containing lorediplon have been used in the treatment of insomnia.

Lorediplon Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lorediplon manufacturers

Dorne Chemical Technology co. LTD
Product
Lorediplon 917393-39-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Shandong Hanjiang Chemical Co., Ltd
Product
Lorediplon 917393-39-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-25

917393-39-6, LorediplonRelated Search:


  • Lorediplon
  • Thionorphine Hydrochloride
  • N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide
  • Acetamide, N-[2-fluoro-5-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methyl-
  • GABA Receptor,γ-Aminobutyric acid Receptor,inhibit,Inhibitor,Lorediplon,Gamma-aminobutyric acid Receptor
  • 917393-39-6