2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide

Product Name: 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
CAS No.: 522650-83-5
Chemical Name: 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
Synonyms: CS-2302;SW-044248;SW-044248, >98%;SW 044248;SW044248;SW044248 >=98% (HPLC);SW 044248,Topoisomerase,inhibit,SW-044248,SW044248,Inhibitor;2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide;Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-;2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide
CBNumber: CB83059120
Molecular Formula: C22H23N5O2S
Formula Weight: 421.52
MOL File: 522650-83-5.mol

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2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide Property

storage temp.: 2-8°C
solubility: DMSO:10.5(Max Conc. mg/mL);24.91(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);11.86(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.37(Max Conc. mM)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1729
Product name: SW044248
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95.7
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1729
Product name: SW044248
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $386
Updated: 2022/05/15

Cayman Chemical

Product number: 23459
Product name: SW044248
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 23459
Product name: SW044248
Purity: ≥98%
Packaging: 10mg
Price: $113
Updated: 2024/03/01

Cayman Chemical

Product number: 23459
Product name: SW044248
Purity: ≥98%
Packaging: 25 mg
Price: $219
Updated: 2024/03/01

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2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide Chemical Properties,Usage,Production

Uses

2-((5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide is a useful intermediate for organic synthesis and other chemical processes.

Biochem/physiol Actions

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. Nos. 208925 & C9911). SW044248 is shown to exhibit antiproliferation efficacy against a subset of non-small-cell lung cancer (NSCLC) cultures (IC50 <5>10 μM) derived from the same patient as HCC4017.

2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide Suppliers

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522650-83-5, 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamideRelated Search:

2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide SW076956

SW 044248;SW044248

CS-2302

SW-044248, >98%

2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide

SW-044248

<br>2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide

Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-

SW044248 >=98% (HPLC)

SW 044248,Topoisomerase,inhibit,SW-044248,SW044248,Inhibitor

522650-83-5