ChemicalBook > CAS DataBase List > MK6-83

MK6-83

Product Name: MK6-83
CAS No.: 1062271-24-2
Chemical Name: MK6-83
Synonyms: MK6-83;spudl 05344;MK6-83 ，S6947;MK6-83, 10 mM in DMSO;5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide;2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-;MK6-83,fibroblast,lysosome,Mucolipidosis,Transient receptor potential channels,cell,inhibit,MK6 83,TRP Channel,MK-6-83,Inhibitor
CBNumber: CB83060610
Molecular Formula: C16H20N2O2S2
Formula Weight: 336.47
MOL File: 1062271-24-2.mol

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MK6-83 Property

Melting point:: 115 - 116°C
Boiling point:: 502.6±60.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
pka: 8.56±0.50(Predicted)
color: Pale Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1509
Product name: MK6-83
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $89.49
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1509
Product name: MK6-83
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $379
Updated: 2025/07/31

Cayman Chemical

Product number: 21944
Product name: MK6-83
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21944
Product name: MK6-83
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 21944
Product name: MK6-83
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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MK6-83 Chemical Properties,Usage,Production

Uses

MK6-83 is a TRPML channel activator, restoring endolysosomal trafficking and zinc homeostasis lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Biological Activity

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.', 'MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

storage

Store at +4°C

MK6-83 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK6-83 Suppliers

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1062271-24-2, MK6-83Related Search:

MK6-83

spudl 05344

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-

MK6-83,fibroblast,lysosome,Mucolipidosis,Transient receptor potential channels,cell,inhibit,MK6 83,TRP Channel,MK-6-83,Inhibitor

MK6-83, 10 mM in DMSO

MK6-83 ，S6947

1062271-24-2