ChemicalBook > CAS DataBase List > KPT 251, >=98%

KPT 251, >=98%

Product Name
KPT 251, >=98%
CAS No.
1388841-50-6
Chemical Name
KPT 251, >=98%
Synonyms
KPT;KPT251;AOB6639;KPT 251, >=98%;SCHEMBL11318201;KPT-251, 10 mM in DMSO;SCHEMBL11318201; AOB6639;;CRM1 Inhibitor IV, KPT-251;2-[(Z)-2-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}vinyl]-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2-[(1Z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-
CBNumber
CB83066960
Molecular Formula
C14H7F6N5O
Formula Weight
375.23
MOL File
1388841-50-6.mol
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KPT 251, >=98% Property

Boiling point:
417.9±55.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 25mg/mL
form 
Solid
pka
-0.42±0.50(Predicted)
color 
Off-white to yellow
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
164589
Product name
KPT 251
Packaging
10mg
Price
$403
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
59392
Product name
KPT 251
Packaging
10mg
Price
$610
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
59392
Product name
KPT251
Packaging
25mg
Price
$650
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
59392
Product name
KPT251
Packaging
100mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC8774
Product name
KPT251
Purity
>98%
Packaging
250mg
Price
$1260
Updated
2021/12/16
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KPT 251, >=98% Chemical Properties,Usage,Production

Uses

KPT 251 is a novel CRM1 inhibitor, which has been shown to be effective in the treatment of acute myeloid leukemia.

Biological Activity

Cell permeable: yes', 'Primary Target
XPO1', 'Reversible: no

in vivo

KPT-251 (75 mg/kg/day; i.g.; three times per week for 5 weeks) effectively suppresses the growth of MV4-11 cells engrafted into NSG mice and provides a significant survival benefit[1].
KPT-251 (50 mg/kg; p.o.; every other day for 21 days) suppresses tumor growth in mice melanoma xenograft models[2].

Animal Model:7-weekold female NOD-SCID-IL2Rcγnull (NSG) mice, introduced 2 × 106 luciferase-expressing MV4-11 cells via tail-vein injections[1]
Dosage:75 mg/kg/day
Administration:Gavage, three times per week for 5 weeks
Result:Exhibited significantly increased survival with leukemia progression occurring only after cessation of treatment, prevented infiltration of leukemia cells into mouse bone marrow and spleen, and spared normal hematopoietic cells.
Animal Model:Athymic nude mice Nu/Nu, melanoma xenograft models[2]
Dosage:50 mg/kg
Administration:Oral, every other day for 21 days
Result:Suppressed tumor growth, increased cleaved caspase-3 and decreased Ki67.

KPT 251, >=98% Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT 251, >=98% Suppliers

China 40 United States 4 Global 44
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4023
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4899
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58

1388841-50-6, KPT 251, >=98%Related Search:


  • KPT 251, >=98%
  • 2-[(Z)-2-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}vinyl]-1,3,4-oxadiazole
  • KPT251
  • AOB6639
  • SCHEMBL11318201
  • SCHEMBL11318201; AOB6639;
  • myeloid leukemia,Apoptosis,KPT 251,Chromosomal Maintenance 1,CRM1,inhibit,Exportin 1,KPT-251,melanoma,XPO1,A375,Inhibitor,antileukemic activity
  • 1,3,4-Oxadiazole, 2-[(1Z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-
  • KPT-251, 10 mM in DMSO
  • CRM1 Inhibitor IV, KPT-251
  • KPT
  • 1388841-50-6
  • C14H7F6N5O