ChemicalBook > CAS DataBase List > KPT 251, >=98%

KPT 251, >=98%

Product Name
KPT 251, >=98%
CAS No.
1388841-50-6
Chemical Name
KPT 251, >=98%
Synonyms
KPT;KPT251;AOB6639;KPT 251, >=98%;SCHEMBL11318201;KPT-251, 10 mM in DMSO;SCHEMBL11318201; AOB6639;;CRM1 Inhibitor IV, KPT-251;2-[(Z)-2-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}vinyl]-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2-[(1Z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-
CBNumber
CB83066960
Molecular Formula
C14H7F6N5O
Formula Weight
375.23
MOL File
1388841-50-6.mol
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KPT 251, >=98% Property

Boiling point:
417.9±55.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 25mg/mL
form 
Solid
pka
-0.42±0.50(Predicted)
color 
Off-white to yellow
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
BA3050
Product name
KPT-251
Packaging
1mg
Price
$139
Updated
2026/05/06
ACHEMBLOCK
Product number
Y227486
Product name
KPT-251
Purity
97.00%
Packaging
5MG
Price
$325
Updated
2026/05/27
ACHEMBLOCK
Product number
Y227486
Product name
KPT-251
Purity
97.00%
Packaging
25MG
Price
$780
Updated
2026/05/27
ACHEMBLOCK
Product number
Y227486
Product name
KPT-251
Purity
97.00%
Packaging
100MG
Price
$2340
Updated
2026/05/27
Arctom
Product number
HY-117996
Product name
KPT-251
Purity
99.92%
Packaging
1mg
Price
$143
Updated
2026/05/26
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KPT 251, >=98% Chemical Properties,Usage,Production

Uses

KPT 251 is a novel CRM1 inhibitor, which has been shown to be effective in the treatment of acute myeloid leukemia.

Biological Activity

Cell permeable: yes', 'Primary Target
XPO1', 'Reversible: no

in vivo

KPT-251 (75 mg/kg/day; i.g.; three times per week for 5 weeks) effectively suppresses the growth of MV4-11 cells engrafted into NSG mice and provides a significant survival benefit[1].
KPT-251 (50 mg/kg; p.o.; every other day for 21 days) suppresses tumor growth in mice melanoma xenograft models[2].

Animal Model:7-weekold female NOD-SCID-IL2Rcγnull (NSG) mice, introduced 2 × 106 luciferase-expressing MV4-11 cells via tail-vein injections[1]
Dosage:75 mg/kg/day
Administration:Gavage, three times per week for 5 weeks
Result:Exhibited significantly increased survival with leukemia progression occurring only after cessation of treatment, prevented infiltration of leukemia cells into mouse bone marrow and spleen, and spared normal hematopoietic cells.
Animal Model:Athymic nude mice Nu/Nu, melanoma xenograft models[2]
Dosage:50 mg/kg
Administration:Oral, every other day for 21 days
Result:Suppressed tumor growth, increased cleaved caspase-3 and decreased Ki67.

KPT 251, >=98% Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT 251, >=98% Suppliers

China 40 United States 4 Global 44
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
982
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58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
sales@changyanchem.cn
Country
China
ProdList
4998
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841 17754423994
Fax
18327183813
Email
candy@biochempartner.com
Country
China
ProdList
3061
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32466
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4032
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4509
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44896
Advantage
58

1388841-50-6, KPT 251, >=98%Related Search:


  • KPT 251, >=98%
  • 2-[(Z)-2-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}vinyl]-1,3,4-oxadiazole
  • KPT251
  • AOB6639
  • SCHEMBL11318201
  • SCHEMBL11318201; AOB6639;
  • myeloid leukemia,Apoptosis,KPT 251,Chromosomal Maintenance 1,CRM1,inhibit,Exportin 1,KPT-251,melanoma,XPO1,A375,Inhibitor,antileukemic activity
  • 1,3,4-Oxadiazole, 2-[(1Z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]ethenyl]-
  • KPT-251, 10 mM in DMSO
  • CRM1 Inhibitor IV, KPT-251
  • KPT
  • 1388841-50-6
  • C14H7F6N5O