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GSK2256294A

Product Name
GSK2256294A
CAS No.
1142090-23-0
Chemical Name
GSK2256294A
Synonyms
GSK2256294A;GSK2256294A, 10 mM in DMSO;GSK 2256294A - GSK 2256294;GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A;(1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide;Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-;GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation
CBNumber
CB83067008
Molecular Formula
C21H24F3N7O
Formula Weight
447.46
MOL File
1142090-23-0.mol
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GSK2256294A Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 47 mg/mL (105.04 mM)
form 
Solid
pka
14.75±0.40(Predicted)
color 
White to off-white
InChIKey
LQHDJQIMETZMPH-ZBFHGGJFSA-N
SMILES
[C@@H]1(C(NCC2=CC=C(C#N)C=C2C(F)(F)F)=O)CCC[C@H](NC2=NC(C)=NC(NC)=N2)C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2220
Product name
GSK 2256294A
Purity
99%
Packaging
2mg
Price
$137.5
Updated
2026/05/19
Axon Medchem
Product number
Axon2220
Product name
GSK 2256294A
Purity
99%
Packaging
5mg
Price
$203.5
Updated
2026/05/19
Axon Medchem
Product number
Axon2220
Product name
GSK 2256294A
Purity
99%
Packaging
25mg
Price
$770
Updated
2026/05/19
aablocks
Product number
AA008TKT
Product name
GSK2256294A
Purity
99%
Packaging
1mg
Price
$59
Updated
2026/05/28
aablocks
Product number
AA008TKT
Product name
GSK2256294A
Purity
99%
Packaging
5mg
Price
$76
Updated
2026/05/28
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GSK2256294A Chemical Properties,Usage,Production

Uses

GSK 2256294 is used in pharmacokinetics, pharmacodynamics and adverse event profile of novel soluble epoxide hydrolase inhibitor GSK2256294 in human against sEH enzyme activity.

in vivo

GSK2256294A (5-30 mg/kg; p.o. twice daily 5 days/week for two weeks) inhibits the generation and maintenance of pulmonary inflammation in cigarette smoke-exposed mice[1]. GSK2256294A (30 mg/kg; p.o. twice daily for 8 days) decreases pulmonary inflammation in cigarette smoke-exposed mice[1].

Animal Model:Mice exposed to cigarette smoke 5 days/week for 2 weeks[1]
Dosage:5 and 30 mg/kg
Administration:Oral gavage; 5 and 30 mg/kg twice daily 5 days/week; for 2 weeks
Result:Dose-dependently inhibited numbers of BAL fluid total cells, neutrophils, macrophages and the keratinocyte chemoattractant (KC) levels in lung tissue.
Animal Model:Mice exposed to cigarette smoke 5 days/week for 2 weeks[1]
Dosage:30 mg/kg
Administration:Oral gavage; 30 mg/kg twice daily; for 8 days
Result:Significantly reduced neutrophils, macrophages and pulmonary inflammation in cigarette smoke-exposed mice.

GSK2256294A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2256294A Suppliers

China 40 India 1 United States 8 Global 49
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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QQ：65489617 19372819560
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21-5161 9052
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Sales@ATKchemical.com
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China
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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1142090-23-0, GSK2256294ARelated Search:


  • GSK2256294A
  • GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A
  • GSK 2256294A - GSK 2256294
  • Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-
  • GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation
  • (1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide
  • GSK2256294A, 10 mM in DMSO
  • 1142090-23-0
  • C21H24F3N7O