GSK2256294A

Product Name: GSK2256294A
CAS No.: 1142090-23-0
Chemical Name: GSK2256294A
Synonyms: GSK2256294A;GSK2256294A, 10 mM in DMSO;GSK 2256294A - GSK 2256294;GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A;(1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide;Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-;GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation
CBNumber: CB83067008
Molecular Formula: C21H24F3N7O
Formula Weight: 447.46
MOL File: 1142090-23-0.mol

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GSK2256294A Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 47 mg/mL (105.04 mM)
form: Solid
pka: 14.75±0.40(Predicted)
color: White to off-white
InChIKey: LQHDJQIMETZMPH-ZBFHGGJFSA-N
SMILES: [C@@H]1(C(NCC2=CC=C(C#N)C=C2C(F)(F)F)=O)CCC[C@H](NC2=NC(C)=NC(NC)=N2)C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: G797420
Product name: GSK2256294
Packaging: 50mg
Price: $1470
Updated: 2021/12/16

Axon Medchem

Product number: Axon2220
Product name: GSK2256294A-GSK2256294
Purity: 99%
Packaging: 5mg
Price: $203.5
Updated: 2021/12/16

ChemScene

Product number: CS-5395
Product name: GSK2256294A
Purity: 99.51%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-5395
Product name: GSK2256294A
Purity: 99.51%
Packaging: 10mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5395
Product name: GSK2256294A
Purity: 99.51%
Packaging: 50mg
Price: $1020
Updated: 2021/12/16

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GSK2256294A Chemical Properties,Usage,Production

Uses

GSK 2256294 is used in pharmacokinetics, pharmacodynamics and adverse event profile of novel soluble epoxide hydrolase inhibitor GSK2256294 in human against sEH enzyme activity.

in vivo

GSK2256294A (5-30 mg/kg; p.o. twice daily 5 days/week for two weeks) inhibits the generation and maintenance of pulmonary inflammation in cigarette smoke-exposed mice^[1]. GSK2256294A (30 mg/kg; p.o. twice daily for 8 days) decreases pulmonary inflammation in cigarette smoke-exposed mice^[1].

Animal Model:	Mice exposed to cigarette smoke 5 days/week for 2 weeks^[1]
Dosage:	5 and 30 mg/kg
Administration:	Oral gavage; 5 and 30 mg/kg twice daily 5 days/week; for 2 weeks
Result:	Dose-dependently inhibited numbers of BAL fluid total cells, neutrophils, macrophages and the keratinocyte chemoattractant (KC) levels in lung tissue.

Animal Model:	Mice exposed to cigarette smoke 5 days/week for 2 weeks^[1]
Dosage:	30 mg/kg
Administration:	Oral gavage; 30 mg/kg twice daily; for 8 days
Result:	Significantly reduced neutrophils, macrophages and pulmonary inflammation in cigarette smoke-exposed mice.

GSK2256294A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2256294A Suppliers

China 35 India 1 United States 8 Global 44

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1142090-23-0, GSK2256294ARelated Search:

GSK2256294A

GSK 2256294;GSK-2256294;GSK2256294;GSK-2256294A;GSK2256294A

GSK 2256294A - GSK 2256294

Cyclohexanecarboxamide, N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]-, (1R,3S)-

GSK-2256294,GSK-2256294A,GSK2256294A,Inhibitor,Epoxide Hydrolase,GSK2256294,inhibit,cigarette smoke-exposure model,oral,COPD,cardiovascular,inflammation

(1R,3S)-N-(4-Cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexane-1-carboxamide

GSK2256294A, 10 mM in DMSO

1142090-23-0

C21H24F3N7O